Quantitative measurement of cartilage volume with automatic cartilage segmentation in knee osteoarthritis
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ORIGINAL ARTICLE
Quantitative measurement of cartilage volume with automatic cartilage segmentation in knee osteoarthritis Wenjing Hou 1 & Jun Zhao 1 & Rui He 2 & Jing Li 1 & Yuan Ou 1 & Mingshan Du 1 & Xuanqi Xiong 1 & Bing Xie 1 & Lian Li 1 & Xiaoyue Zhou 3 & Panli Zuo 3 & Esther Raithel 4 & Zhuoli Zhang 5 & Wei Chen 1 Received: 13 February 2020 / Revised: 19 August 2020 / Accepted: 1 September 2020 # International League of Associations for Rheumatology (ILAR) 2020
Abstract Purpose To determine the reproducibility of the automatic cartilage segmentation method using a prototype KneeCaP software (version 1.3; Siemens Healthcare, Erlangen, Germany) and to compare the difference in cartilage volume (CV) between the normal knee joint and knee osteoarthritis (KOA) of different degrees by using the above software. Materials and methods The study included 62 subjects with knee OA and 29 healthy control subjects. The cartilage lesion patients were divided into a mild-to-moderate OA group (n = 29) and severe OA group (n = 33). Automatic cartilage segmentation was performed on all the subjects, and among them, 19 knee cases were randomly selected to also do the manual cartilage segmentation. Statistical significance was determined with one-way analysis of variance (ANOVA), intraclass correlation coefficient (ICC), and Pearson correlation coefficient. Automatic segmentation was compared with the manual one. The relative cartilage volume percentages of the femur, tibia, and patella in the normal control/mild-to-moderate/severe OA groups were assessed. Results Comparing the cartilage volumes derived by manual and automatic segmentation, the ICC value for the knee joint, patella, femur, or tibia was 0.784, 0.815, 0.740, and 0.797. The relative cartilage volume percentages of the femur, tibia, and patella in the normal control/mild-to-moderate/severe OA groups were 57.28%/59.30%/62.45% (femur), 25.35%/23.46%/21.84% (tibia), and 17.37%/17.24%/15.71% (patella), respectively. Compared with the normal control group, the relative tibia cartilage volume percentage was lower in the mild-to-moderate OA group and the severe OA group. Corresponding index showed a similar difference between the mild-to-moderate OA group and the severe OA group (p < 0.001). Conclusion This study demonstrated that the relative cartilage volume percentage is correlated with the semi-quantitative systems and may be a preferred outcome measure in clinical studies of OA. Automatic cartilage segmentation using KneeCaP delivered reliable results on high-spatial-resolution 3 T MR images for the healthy, mild-moderate OA patients.
Wenjing Hou, Jun Zhao and Wei Chen contributed equally to this work. In the present study, we found that the relative cartilage volume percentage is correlated with the semi-quantitative systems and may be a preferred outcome measure in clinical studies of OA. Automatic cartilage segmentation using KneeCap delivered reliable results on highspatial-resolution 3T MR images for the healthy, mild-moderate OA patients * Wei Chen landcw@hot
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