Quantity and quality of muscle in patients recently diagnosed with colorectal cancer: a comparison with cancer-free cont
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ORIGINAL ARTICLE
Quantity and quality of muscle in patients recently diagnosed with colorectal cancer: a comparison with cancer-free controls Mayra Cruz-Fernández 1,2 & Alexander Achalandabaso-Ochoa 3 & Tania Gallart-Aragón 4 & Francisco Artacho-Cordón 1,2,5,7 & María José Cabrerizo-Fernández 6 & Nicolás Pacce-Bedetti 2 & Irene Cantarero-Villanueva 1,2,7 Received: 5 August 2019 / Accepted: 16 January 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract This cross-sectional study compares the muscle mass, core strength and physical fragility of patients recently diagnosed with colorectal cancer (pRD-CRC) with those of healthy subjects and identifies variables to be considered when designing pretreatment physical interventions for such patients. Body composition, anthropometric variables, the muscle architecture of the lumbopelvic region, physical fitness and frailty were assessed in 32 pRD-CRC and 29 healthy control subjects. The patients showed a reduction in muscle mass (F = 10.059; P = 0.003), in the width of the lumbar multifidus (F = 21.869; P < 0.001), in the transverse abdominal muscle (U = 323.00; P = 0.042) and in the abdominal strength resistance (F = 12.264; P = 0.001). They were also frailer (P = 0.002) than the controls. These results suggest that pRD-CRC are affected by reduced strength and myopenia, leading to frailty. The early incorporation of these patients into strength-enhancing programs may be advisable. Keywords Colorectal cancer . Fragility . Muscle mass loss . Physical fitness . Strength
Introduction The number of patients who survive cancer is increasing [1]; they may, however, have special healthcare needs due to the consequence of sequelae of the disease itself and the treatment * Irene Cantarero-Villanueva [email protected] 1
“Cuídate” Support Unit for Oncology Patients (UAPO), Sport and Health University Research Institute (iMUDS, University of Granada, Granada, Spain
2
Department of Physiotherapy, University of Granada, Granada, Spain
3
Department of Health Sciences, Faculty of Health Sciences, University of Jaén, Jaén, Spain
4
Unit of Mammary Pathology, General Surgery Services, “Campus de la Salud” Hospital, Granada, Spain
5
Department of Radiology and Physical Medicine, University of Granada, Granada, Spain
6
General Surgery Unit, “Campus de la Salud” Hospital, Granada, Spain
7
Biohealth Research Institute in Granada (ibs.GRANADA), University Hospital Complex of Granada, University of Granada, Granada, Spain
they have undergone [2]. This situation is especially true in patients who had colorectal cancer (CRC). In addition to dealing with the common sequelae of cancer, they face digestive disturbances [2–4] and may experience structural and functional problems in the central part of the body [3]—an area with important functions for body core stability. These problems can have a serious negative effect on the quality of life long after completing the treatment [5] and can incur important healthcare costs [6]. There is, therefore, a growing int
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