Quartz tuning fork as a mass sensitive biosensor platform with a bi-layer film modification via plasma polymerization
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Quartz tuning fork as a mass sensitive biosensor platform with a bi-layer film modification via plasma polymerization Hatice Ferda Özgüzar, Plasma Aided Biomedical Research Group (pabmed), Biomedical Engineering Division, Graduate School of Science and Technology, TOBB University of Economics and Technology, Ankara 06560, Turkey Gizem Kaleli Can*, Plasma Aided Biomedical Research Group (pabmed), Biomedical Engineering Division, Graduate School of Science and Technology, TOBB University of Economics and Technology, Ankara 06560, Turkey; Department of Biomedical Engineering, I˙zmir Democracy University, I˙zmir 35140, Turkey Gözde Kabay, Plasma Aided Biomedical Research Group (pabmed), Biomedical Engineering Division, Graduate School of Science and Technology, TOBB University of Economics and Technology, Ankara 06560, Turkey Mehmet Mutlu, Plasma Aided Biomedical Research Group (pabmed), Biomedical Engineering Division, Graduate School of Science and Technology, TOBB University of Economics and Technology, Ankara 06560, Turkey; Plasma Aided Biomedical Research Group (pabmed), Department of Biomedical Engineering, TOBB University of Economics and Technology, Ankara 06560, Turkey Address all correspondence to Mehmet Mutlu at [email protected] (Received 4 February 2019; accepted 19 April 2019)
Abstract Due to the lack of the stability of amine films, a promising transducer, quartz-tuning fork (QTF) prongs were modified by a bi-layer film of plasma-polymerized n-heptane (hep) and then by ethylenediamine (EDA), respectively. For this purpose, the authors investigate the stability of amine-rich thin films both in air and aqueous medium. EDA films were deposited on QTF substrates by using an RF plasma system. The final amine-rich thin film was used to immobilize biologic recognition element. Model protein studies were showed that selected thin films could be adapted to QTF transducers to be used as a biosensor template.
Introduction Plasma polymerization (PP) technique is an environmentally friendly, low cost, highly reproducible, and versatile method to obtain more stable thin films compared with films prepared by chemical methods such as self-molecular assembly, layer-by-layer, or spin coating.[1] This process is capable of creating thin films, which control films’ growth down to angstrom (Å) size and it provides uniform coating by preserving bulk properties of the substrate material. Until today, plasmapolymerized thin films (PPTFs) have been investigated for use in many areas especially biomedical applications and biotechnology. Besides, PP technique has been studied by our group and the others to modify physical, chemical, electrical, or biologic properties of materials mainly for biotechnological applications.[1–8] In particular, adjustable chemical composition of thin films achieved by plasma modification has become vital over the years, which indirectly influences the performance and the functionality of polymers for suitable applications.[9] Within PPTFs, amino-group functionalized ones (NH2-PPTFs) have been frequentl
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