Quercetin attenuates cisplatin-induced fat loss
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ORIGINAL CONTRIBUTION
Quercetin attenuates cisplatin‑induced fat loss Yi‑Chin Lin1 · Li‑wen Chen1 · Yun‑Chu Chen1 · Shu‑Ting Chan1 · Jiunn‑Wang Liao2 · Shu‑Lan Yeh1,3 Received: 13 May 2020 / Accepted: 19 August 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose The major aim of the present study was to determine the effects of quercetin, a well-known flavonoid, on attenuating cisplatin (CDDP)-induced fat loss and the possible mechanisms. Methods Tumor-bearing nude mice and tumor-free BALB/c mice were administrated with CDDP alone or in combination with quercetin by a diet containing 0.1% or 1% quercetin (LQ or HQ) or by intraperitoneal injection (IQ) to determine the effects of quercetin on the anticancer effect of CDDP or CDDP-induced fat loss. The effects of quercetin on fat accumulation in CDDP-exposed 3T3-L1 cells were also determined. Results We first showed that HQ and IQ significantly enhanced the anticancer effect of CDDP by upregulating p53- and p21-associated pathways, while tended to attenuate CDDP-induced fat loss in tumor-bearing nude mice. The study in 3T3-L1 cells showed that CDDP decreased the fat accumulation accompanied by strong upregulation of the expression of six genes which are associated with fat metabolism, while quercetin completely suppressed such an effect. The tumor-free BALB/c mice study consistently showed a protective effect of HQ on CDDP-induced body weight and epididymal fat loss. HQ also increased the fat levels in liver and muscle tissues. In epididymal fat tissues, HQ consistently attenuated CDDP-induced changes in fat metabolism-associated gene expression. However, CDDP alone or in combination with HQ did not affect the food intake. Conclusions This study demonstrates that quercetin possesses the potential to suppress CDDP-induced fat loss may partly through the regulation of the fat metabolism-associated gene expression. Keywords Cisplatin · Quercetin · Fat loss · Fat metabolism
Introduction Body fat plays an important role in energy homeostasis and body weight regulation. Depletion of body fat stores is associated with reduced quality of life in patients with cancer and shorter survival independent of body mass index [1, 2]. Besides cancer itself, the abnormalities in lipid metabolism and consequent fat loss are also caused by many cytotoxic
* Shu‑Lan Yeh [email protected] 1
Department of Nutritional Science, Chung Shan Medical University, No. 110 Sec 1 Jianguo N. Rd, Taichung, Taiwan, ROC
2
Graduate Institute of Veterinary Pathology, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan
3
Department of Nutrition, Chung Shan Medical University Hospital, Taichung, Taiwan
chemotherapeutic agents such as cisplatin (CDDP). CDDP is an inorganic platinum-based chemotherapeutic agent which is being widely administered for treatment of various cancers such as lung, head and neck, ovary and bladder cancer in clinical situations [3]. However, it can cause DNA damage, inhibit protein synthesis, genera
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