PPARGC1A gene polymorphism is associated with exercise-induced fat loss
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ORIGINAL ARTICLE
PPARGC1A gene polymorphism is associated with exercise‑induced fat loss Iuliia Iu. Mazur1 · Svitlana Drozdovska1 · Olena Andrieieva1 · Yulia Vinnichuk1 · Anna Polishchuk1 · Victor Dosenko2 · Igor Andreev3 · Craig Pickering4 · Ildus I. Ahmetov5,6,7 Received: 12 March 2020 / Accepted: 3 September 2020 © Springer Nature B.V. 2020
Abstract Obesity is a widespread problem within modern society, serving to increase the risk of cardiovascular, metabolic, and neurodegenerative disorders. Peroxisome proliferator-activated receptor gamma (PPARγ) and PPARγ coactivator 1 α (PGC1α) play a key role in the regulation of cellular energy metabolism and is implicated in the pathology of these diseases. This study examined the association between polymorphisms of the PPARGand PPARGC1A genes and individual variability in weight loss in response to physical activity intervention. 39 obese Ukrainian women (44.4 ± 7.5 years, BMI > 30.0 kg/m2) undertook a 3-month fitness program whilst following a hypocaloric diet (~ 1500 cal). Anthropometric and biochemical measurements took place before and after the program. Single nucleotide polymorphisms within or near PPARG(n = 94) and PPARGC1A (n = 138) were identified and expression of PPARGmRNA was measured via reverse transcription and amplification. The association between DNA polymorphisms and exercise-induced weight loss, initial body mass, biochemistry and PPARG expression was determined using one-way analysis of variance (ANOVA). The present intervention induced significant fat loss in all participants (total fat: 40.3 ± 5.3 vs 36.4 ± 5.7%; P
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