Racing for the Surface Pathogenesis of Implant Infection and Advance
This book covers the latest research in biofilm, infection, and antimicrobial strategies in reducing and treating musculoskeletal, skin, transfusion, implant-related infections, etc. Topics covered include biofilms, small colony variants, antimicrobial bi
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Racing for the Surface
Pathogenesis of Implant Infection and Advanced Antimicrobial Strategies
Racing for the Surface
Bingyun Li • Thomas Fintan Moriarty Thomas Webster • Malcolm Xing Editors
Racing for the Surface Pathogenesis of Implant Infection and Advanced Antimicrobial Strategies
Editors Bingyun Li Department of Orthopaedics West Virginia University Morgantown, WV, USA
Thomas Fintan Moriarty Microbiology Lab AO Research Institute Davos Davos Platz, GR, Switzerland
Thomas Webster Department of Chemical Engineering Northeastern University Boston, MA, USA
Malcolm Xing Engineering and Medicine University of Manitoba Winnipeg, MB, Canada
ISBN 978-3-030-34474-0 ISBN 978-3-030-34475-7 (eBook) https://doi.org/10.1007/978-3-030-34475-7 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Foreword
With the implantation of new devices and novel technologies to mitigate pain and improve function, unforeseen, sometimes serious complications are currently being observed that may limit the lifetime of the implant. In orthopedic surgery, chief amongst these adverse events is implant infection. Whether the implant is a permanent prosthesis (such as in joint replacement or a spinal device), or a biodegradable polymeric device (e.g., for fracture fixation or reconstruction of deficient ligaments), acute and chronic infection can occur. Infection of an implant induces local inflammation, subsequent pain and poor function, and may necessitate removal of the implant, aggressive debridement of the local tissues, and prolonged antibiotic treatment. Infections of orthopedic implants are a substantial burden to society and the healthcare system and a devastatin
