Radiation Proteomics The effects of ionizing and non-ionizing radiat

Proteomics is widely used in search of biomarkers, pharmacology, clinical research and toxicology. With the help of proteomics large amount of information about the physiology of living cells can be obtained in a single experiment. Combining this informat

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Editorial Board: IRUN R. COHEN, The Weizmann Institute of Science ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research JOHN D. LAMBRIS, University of Pennsylvania RODOLFO PAOLETTI, University of Milan

For further volumes: http://www.springer.com/series/5584

Dariusz Leszczynski Editor

Radiation Proteomics The effects of ionizing and non-ionizing radiation on cells and tissues


Editor Dariusz Leszczynski STUK Radiation and Nuclear Safety Authority Helsinki, Finland

ISSN 0065-2598 ISBN 978-94-007-5895-7 ISBN 978-94-007-5896-4 (eBook) DOI 10.1007/978-94-007-5896-4 Springer Dordrecht Heidelberg New York London Library of Congress Control Number: 2013931102 © Springer Science+Business Media Dordrecht 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)


Proteomics is widely used in search of biomarkers, in pharmacology, in clinical research and in toxicology. With the help of proteomics, large amount of information on the physiology of living cells can be obtained in a single experiment. Combining this information with the data from genomics and other high-throughput screening techniques, like transcriptomics and metabolomics, allows researchers to gain new insights into the normal and pathological physiology of cells, tissues and organisms. The