Radiochemical Synthesis of Au/Iron-oxide Composite Nanoparticles Using PEG
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1064-PP06-01
Radiochemical Synthesis of Au/Iron-oxide Composite Nanoparticles Using PEG Satoshi Seino1, Takuya Kinoshita2, Juinichi Iida1, Yujin Shibata1, Takashi Nakagawa3, Koji Ueno4, and Takao A Yamamoto1 1 Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan 2 Graduate School of Engineering, Osaka Prefecture University, 1-1 Gakuencho, Sakai, Osaka, 599-8531, Japan 3 Graduate School of Science and Engineering, Tokyo Institute of Technology, 2-12-1 Ookayama,Meguro-ku, Tokyo, 152-8552, Japan 4 Japan Electron Beam Irradiation Service Co. Ltd., 5-3 Ozushimacho, Izumiotsu, Osaka, 5950074, Japan ABSTRACT Composite nanoparticles consisting of gold and iron-oxide were radiochemically synthesized in aqueous solution systems by using polyethylene glycols. The gold particles with average diameter of 3 nm were firmly immobilized on the surface of the support iron-oxide nanoparticles. The composite nanoparticles specifically adsorbed sulfur-containing amino acids by a Au-S bonding. INTRODUCTION In recent years, magnetic nanoparticles are widely studied because of their potential applications as magnetic carriers for various biomedical uses [1-6]. For practical applications, their surfaces are coated with appropriate layer to combine with the functional biomolecules for each purpose and to avoid nonspecific adsorption. For the in-vivo application of nanoparticle materials, polyethylene glycols (PEG) are most commonly studied to avoid the biofouling and enhance the half life in the blood [7, 8]. Composite nanoparticle consisting of gold and magnetic iron oxide is one of the candidates for new type of nanocarrier [9-12]. As the gold combines firmly with biomolecules via S-Au bonds [13, 14], the gold part can be used as a general tag for functional biomolecules. Recently, our group succeeded in synthesizing composite nanoparticles consisting of magnetic iron oxide nanoparticles and gold nanoparticles supported on its surface by using radiation energy [15, 16]. To enhance the specific adsorption and suppress the nonspecific adsorption, it is necessary to reduce the size of Au grains on the iron oxide nanoparticles [17]. In these processes, polyvinyl alcohol (PVA) was used to control the size of Au grains. These polymers are considered to be physically adsorbed onto the surface of the composite nanoparticles [18]. In this paper, we report on the synthesis of Au/iron-oxide composite nanoparticles using PEG as the polymer material. PEG is generally used to improve the biocompatibility and blood circulation times in vivo, since it resists the deposition of nonspecific proteins [19, 20]. We expect that the PEG physically adsorbed onto the surface of composite nanoparticles and show its functionalities. Since PEG easily suffer decomposition and/or cross-linking reaction by the ionizing radiation, the synthesis condition should be carefully controlled. Adsorption affinity of biomolecules has been checked by using amino acids as model compound.
EXPERIMENT Experimental conditions for synthesizin
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