Recent Advances in the Pathophysiology of COPD

Chronic obstructive pulmonary disease (COPD) ranges amongst the commonest diseases in the world. The relentless progression of the disease causes a pressing need for a better understanding of and therapies for COPD. This volume provides state-of-the-art i

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Series Editor Prof. Dr. Michael J. Parnham Senior Scientific Advisor PLiVA dd Prilaz baruna Filipovica 25 10000 Zagreb Croatia

Advisory Board G. Z. Feuerstein (Merck Research Laboratories, West Point, PA, USA M. Pairet (Boehringer Ingelheim Pharma KG, Biberach a. d. Riss, Germany) W. van Eden (Universiteit Utrecht, Utrecht, The Netherlands)

Forthcoming titles: Cancer and Inflammation, D.W. Morgan, M. Nakada, U. Forssmann (Editors), 2004 Anti-Inflammatory or Anti-Rheumatic Drugs, R.O. Day, D.E. Furst, P.L. van Riel (Editors), 2004 Cytokines and Joint Iniury, P. Miossec, W.B. van den Berg (Editors), 2004 Antibiotics as Antiinflammatory and Immunomodulatory Agents, B. Rubin, J. Tamaoki (Editors), 2004 (Already published titles see last page.)

Recent Advances in the Pathophysiology of COPD

T. T. Hansel P. J. Barnes

Editors

Springer Basel AG

Editors Trevor T. Hansel NHLI Clinical 5tudies Unit Royal Brompton Hospital Fulham Road London 5W3 6HP United Kingdom

Peter J. Barnes Department of Thoraic Medicine National Heart and Lung Institute Imperial College Dovehouse 5t. London 5W3 6LY United Kingdom

A CIP catalogue record for this book is available from the Library of Congress, Washington D.C., USA

Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the internet at http://dnb.ddb.de

The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that theyare exempt from the relevant protective laws and regulations or free for general use.

ISBN 978-3-0348-9628-3 ISBN 978-3-0348-7939-2 (eBook) DOI 10.1007/978-3-0348-7939-2 This work is subject to copyright. AII rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must be obtai ned.

© 2004 Springer Basel AG Originally published by Birkhăuser Verlag in 2004 softcover reprint of the hardcover 1st edition 2004

Printed on acid-free paper produced from chlorine-free pulp. TCF ~ Cover design: Markus Etterich, Basel Cover iIIustration: Centrilobular emphysema (see p. 51)

ISBN 978-3-0348-9628-3 987654321

www.birkhauser-science.com

Contents

List of contributors

vii

Jian-Qing He, Scott 1. Tebbutt and Peter D. Pare Genetics of COPD . . . . . . . . . . . . . . . .......... . Simonetta Baraldo, Renzo Zuin and Marina Saetta The pathology of COPD .................................... . Frances Gilchrist, Onn Min Kon and Michael I. Polkey Lung function in COPD ................................. Rach