Recent Advances of Persistent Luminescence Nanoparticles in Bioapplications
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REVIEW
Cite as Nano-Micro Lett. (2020) 12:70 Received: 24 December 2019 Accepted: 2 February 2020 © The Author(s) 2020
https://doi.org/10.1007/s40820-020-0404-8
Recent Advances of Persistent Luminescence Nanoparticles in Bioapplications Shuqi Wu1, Yang Li1, Weihang Ding1, Letong Xu1, Yuan Ma2, Lianbing Zhang1 * * Lianbing Zhang, [email protected] School of Life Sciences, Key Laboratory of Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi’an 710072, People’s Republic of China 2 School of Materials Science and Engineering, Northwestern Polytechnical University, Xi’an 710072, People’s Republic of China 1
HIGHLIGHTS • Comprehensive summary on properties, persistent luminescence mechanism and synthesis of persistent luminescence nanoparticles. • Unique properties and advantages of persistent luminescence nanoparticles for chem/biosensing, bioimaging and imaging-guided therapy. • New organic and polymeric persistent luminescence nanoparticles with long afterglow lifetime for in vivo optical imaging.
ABSTRACT Persistent luminescence phosphors are a novel
sol-gel method template method hydrothermal method EDTA etching ...
group of promising luminescent materials with afterglow properties after the stoppage of excitation. In the past decade, persis-
to the efficient elimination of the autofluorescence interfer-
of PLNPs in biosensing, cell tracking, bioimaging and cancer designing new types of PLNPs with desired superior characteristics and multiple functions. In this review, we summarize the works on synthesis methods, bioapplications, biomembrane modification and biosafety of PLNPs and highlight the recent
second or thirdbiological window
g
therapy. These achievements stimulated the growing interest in
cell tracking multimodal imaging
gin ma
emission, many researches have focused on the manipulation
i Bio
ences from biotissues and the ultra-long near-infrared afterglow
PLNPs Therapy
L. reuteri biofilm RBC membrane 4T1 cell membrane
e an br em g om atin co
tions in biomedical fields have been widely explored. Owing
Synthesis
Bi
areas. Especially in recent years, the development and applica-
α-fetoprotein glutathione caspase-3 microRNA isocarbophos
O po rgan ic ly PL meri / NP c s
properties have attracted a wide range of attention in various
Ch e se m/b ns ioing
tent luminescence nanoparticles (PLNPs) with intriguing optical
AIE dots semiconducting NPs image guidedcancer surgery
photodynamic therapy photothermal therapy drug delivery and chemotherapy
advances in biosensing, imaging and imaging-guided therapy. We further discuss the new types of PLNPs as a newly emerged class of functional biomaterials for multiple applications. Finally, the remaining problems and challenges are discussed with suggestions and prospects for potential future directions in the biomedical applications. KEYWORDS Persistent luminescence nanoparticles; Biosensing; Bioimaging; Cell tracking; Cancer therapy
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1 Introduction Afterglow or persist
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