Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease
Receptor tyrosine kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases, and over the last decade have become the number one targets of cancer drugs. Receptor Tyrosine Kinase: Structure, Functions and Role in Human Di
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Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease
Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease
Deric L. Wheeler • Yosef Yarden Editors
Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease
Editors Deric L. Wheeler Department of Human Oncology University of Wisconsin Madison, WI, USA
Yosef Yarden Department of Biological Regulation Weizmann Institute of Science Rehovot, Israel
ISBN 978-1-4939-2052-5 ISBN 978-1-4939-2053-2 (eBook) DOI 10.1007/978-1-4939-2053-2 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2014954081 © Springer Science+Business Media New York 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is a brand of Springer Springer is part of Springer Science+Business Media (www.springer.com)
This book is dedicated to the memory of Anthony (Tony) Pawson, who passed away in August 2013 (age 60). Tony was born and educated in England and lived in Canada. His research has revolutionized our understanding of tyrosine phosphorylation networks and signal transduction in general. Many of the principles and examples discussed in these handbooks were laid down by Tony’s pioneering work uncovering the phosphotyrosine-binding Src homology 2 (SH2) domain, a prototype module of phosphorylation-based protein-pr
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