Recurrent Implantation Failure Etiologies and Clinical Management
This unique text discusses the wide range of causes and pathophysiologic conditions contributing to recurrent implantation failure (RIF) and the current treatment approaches to best approach this challenging patient population. Beginning with a presentati
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Recurrent Implantation Failure
Jason M. Franasiak • Richard T. Scott Jr. Editors
Recurrent Implantation Failure Etiologies and Clinical Management
Editors Jason M. Franasiak Reproductive Medicine Associates of NJ Thomas Jefferson University Basking Ridge, NJ USA
Richard T. Scott Jr. Reproductive Medicine Associates of NJ Thomas Jefferson University Basking Ridge, NJ USA
ISBN 978-3-319-71966-5 ISBN 978-3-319-71967-2 (eBook) https://doi.org/10.1007/978-3-319-71967-2 Library of Congress Control Number: 2018930026 © Springer International Publishing AG 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by the registered company Springer International Publishing AG part of Springer Nature The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
To my wife, Kaitlin, who is my constant. Without your love and support, this book would not have been possible. Jason M. Franasiak
Preface
We are fortunate to practice reproductive medicine during a time of unprecedented success when it comes to assisted reproductive technology. With the advent of comprehensive chromosomal screening, the contribution of aneuploidy to implantation failure has been all but eliminated. Still, though, euploid embryos fail to implant. Why is that? The dwindling rate of implantation failure makes the remaining cases a particular challenge for both practitioners and their patients. The very workup for recurrent implantation failure, let alone available treatment options, often remains elusive. This text is unique in its multifaceted approach to thinking about these challenging cases. It starts with a foundational look at the signaling between the embryo and endometrium, which leads to the management of embryo and endometrial synchrony. The pathologic nature of implantation failure is then ex
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