Recurrent implantation failure: which patients benefit from endometrial scratching prior to IVF?
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GYNECOLOGIC ENDOCRINOLOGY AND REPRODUCTIVE MEDICINE
Recurrent implantation failure: which patients benefit from endometrial scratching prior to IVF? Guy Bar1 · Avi Harlev1 · Samira Alfayumi‑Zeadna2 · Atif Zeadna1 · Ilia Bord1 · Iris Har‑Vardi1 · Eitan Lunenfeld1 · Eliahu Levitas1 Received: 2 July 2019 / Accepted: 17 December 2019 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Endometrial scratching (ES) using a biopsy catheter prior to the IVF cycle in the repeated implantation failure (RIF) population has been suggested, but no convincing evidence of its benefit has been presented until now. Methods A retrospective mono-center study among 300 consecutive IVF-RIF cycles following evaluation of the ovarian reserve, hysterosalpingography or hysteroscopy, pelvic ultrasound, thrombophilia evaluation, karyotyping and assessment of male sperm parametrs. The findings within normal limits. All the patients offered ES, 78 consented and underwent ES prior to their next IVF cycle. Results A comparison of treatment outcomes between the post-ES cycles (n = 78) and the non-ES cycles (222) demonstrated the following: 34 (43.5%) versus 14 (6.3%) conceptions, respectively (p = 0.001) and 30 (38.4%) versus 2 (0.9%) clinical pregnancies, respectively (p
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