Recurrent mantle cell lymphoma in the uterine cervix: a case report
- PDF / 928,586 Bytes
- 4 Pages / 595.276 x 790.866 pts Page_size
- 36 Downloads / 231 Views
(2020) 14:138
CASE REPORT
Open Access
Recurrent mantle cell lymphoma in the uterine cervix: a case report Giusi Santangelo* , Innocenza Palaia, Giorgia Perniola, Anna Di Pinto, Angela Musella, Federica Tomao, Margherita Fischetti, Carolina Sassu, Mariagrazia Piccioni, Violante Di Donato and Pierluigi Benedetti Panici
Abstract Background: Mantle cell lymphoma is one of several subtypes of non-Hodgkin lymphoma. Cervical relapse of nonHodgkin lymphoma is a very rare condition that has a variable and nonspecific presentation and may resemble other neoplastic or inflammatory conditions. Case presentation: Our patient was a 58-year-old Caucasian woman who experienced relapse of mantle cell lymphoma with cervical localization. She complained of postmenopausal vaginal bleeding, bladder pressure, and rapid growth of a cervical lesion. An irregular tumor mass of the cervix was visualized during gynecological examination, with findings highly suggestive of locally advanced cervical cancer. Surprisingly, the biopsies showed an extra nodal relapse of mantle cell lymphoma in the cervix. The rarity of this presentation and the scarcity of clinical studies make this type of recurrence very aggressive and difficult to treat. Conclusions: Obtaining a definitive histological diagnosis by biopsy or surgical resection and starting appropriate therapy are essential for recovery and treatment of these patients, even if the prognosis is poor. Keywords: Aggressive non-Hodgkin lymphoma, Cervix, Mantle cell lymphoma, Quality of life, Relapse, Postmenopausal vaginal bleeding
Introduction Mantle cell lymphoma (MCL) is one of several subtypes of non-Hodgkin lymphoma (NHL). MCL is the rarest of the subtypes, accounting for about 6% of all NHL cases in the United States and Europe. It is the result of a malignant transformation of a B lymphocyte in the outer edge of a lymph node follicle, called the “mantle zone.” Those cells can spread through the lymphatics and blood to other lymph nodes or tissues, such as the bone marrow, liver, and gastrointestinal tract. MCL has the worst prognosis among lymphomas, with a median survival of approximately 3–4 years [1]. Lymphoid neoplasms of the female genital organs are relatively rare, accounting for less than 5% of extranodal * Correspondence: [email protected] Department of Maternal and Child Health and Urological Sciences, Policlinico “Umberto I”, University “Sapienza”, Viale del Policlinico, 155, 00161 Rome, Italy
lymphomas. We conducted a literature search of PubMed and MEDLINE using the keywords “cervix,” “mantle cell lymphoma,” and “lymphoma.” We found no reports of MCL involving the uterine cervix. We present a case of a patient with a cervical relapse of NHL with a rare presentation. This condition is very rare and, to our knowledge, has never been described in the literature. The aim of this case report is to remind clinicians to think of cervical relapse of NHL in cases of vaginal bleeding in women with a history of NHL.
Case presentation A 58-year-old Caucasian woman complaini
Data Loading...
