Reduced serum CTRP12 levels in type 2 diabetes are associated with renal dysfunction
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NEPHROLOGY - ORIGINAL PAPER
Reduced serum CTRP12 levels in type 2 diabetes are associated with renal dysfunction Jinqiu Du1 · Jiajia Xu1 · Xiaoguang Wang1 · Yanyan Liu1 · Xue Zhao1 · Huijuan Zhang1 Received: 8 April 2020 / Accepted: 27 July 2020 © Springer Nature B.V. 2020
Abstract Purpose Serum C1q/TNF-related protein-12 (CTRP12) is one of the newly studied families of adipokines, which is believed to be associated with type 2 diabetes. However, the relationship between serum CTRP12 levels and diabetic nephropathy remains unclear. This study aimed to investigate the relationship between serum CTRP12 levels and renal function in patients with type 2 diabetes. Methods A total of 115 type 2 diabetic patients and 54 healthy subjects were enrolled in this study. 52 patients with type 2 diabetes were in the diabetes group (T2DM). The 63 patients with renal dysfunction were diabetic nephropathy group (T2DM-DN) and were divided into microalbuminuria subgroup (31 cases) and macroalbuminuria subgroup (32 cases) according to the 24-h urine protein excretion rate. The concentrations of serum CTRP12 were determined by enzyme-linked immunosorbent assay. Results Serum CTRP12 level in T2DM and T2DM-DN groups was significantly lower compared with the control group, while CTRP12 level in T2DM-DN group was significantly lower than that in T2DM group, and was associated with the severity of renal insufficiency. After adjusting for gender and age, serum CTRP12 level was negatively correlated with the duration of diabetes, blood urea nitrogen (BUN), uric acid (UA) and 24-h urinary albumin excretion rate (UAE) in T2DM patients. Logistic regression analysis showed that serum CTRP12 level was significantly associated with renal dysfunction in type 2 diabetes mellitus. And the duration of diabetes, total cholesterol (CHOL) and neutrophils/lymphocytes (NLR) are independent risk factors for renal dysfunction in type 2 diabetes mellitus. Conclusion Serum CTRP12 may be involved in the occurrence and development of diabetic nephropathy. Trial registration number and date of registration ChiCTR2000030794, March 14, 2020. Keywords C1q/TNF-related protein-12 (CTRP12) · Type 2 diabetes · Diabetic renal dysfunction · Adipocytokines
Introduction Adipose tissue is not only a storage organ for fat, but also an active endocrine and paracrine organ [1], which can produce various biologically active proteins called adipokines, such as leptin, adiponectin, tumor necrosis factor-a (TNF-α), Interleukin (IL)-6 [2]. The CTRP family was first discovered by Wong et al. [3], including CTRP1-15, and they all have a common structure consisting of an amino-terminal signal peptide, a short variable region, a collagen-like domain, and * Huijuan Zhang [email protected] 1
Department of Endocrinology and Metabolic Diseases, First Affiliated Hospital of Harbin Medical University, Harbin 150000, China
a carboxyl group. It is composed of a spherical domain at the end, of which the carboxyl-terminal spherical domain is an important structure that plays a biologica
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