Regenerating the Heart Stem Cells and the Cardiovascular System
Medical research made huge strides in treating heart disease in the 20th century, from drug-eluding stents to automatic internal defibrillators. Public awareness of the dangers of heart disease has never been more pervasive. Now, though, ten years into a
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Ira S. Cohen • Glenn R. Gaudette Editors
Regenerating the Heart Stem Cells and the Cardiovascular System
Editors Ira S. Cohen Department of Physiology and Biophysics Stony Brook University Stony Brook, NY USA [email protected]
Glenn R. Gaudette Department of Biomedical Engineering Worcester Polytechnic Institute Worcester, MA USA [email protected]
ISBN 978-1-61779-020-1 e-ISBN 978-1-61779-021-8 DOI 10.1007/978-1-61779-021-8 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011922496 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Contents
1 Introduction................................................................................................ Ira S. Cohen and Glenn R. Gaudette
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Part I Stem Cells for Regeneration of Mechanical Function 2 Inducing Embryonic Stem Cells to Become Cardiomyocytes................ Alexander M. Becker, Michael Rubart, and Loren J. Field 3 Regenerating Function In Vivo with Myocytes Derived from Embryonic Stem Cells...................................................................... Priya R. Baraniak and Todd C. McDevitt 4 Excitation–Contraction Coupling, Functional Properties, and Autonomic and Hormonal Regulation in Human Embryonic Stem Cell Derived Cardiomyocytes...................................... Oshra Sedan and Ofer Binah
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5 Embryonic Stem Cell Derivatives for Cardiac Therapy: Advantages, Limitations, and Long-Term Prospects.............................. Michal Weiler-Sagie and Lior Gepstein
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6 Methods for Differentiation of Bone-Marrow-Derived Stem Cells into Myocytes........................................................................... Shinji Makino and Keiichi Fukuda
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