Stem Cells and Cancer Stem Cells,Volume 3 Stem Cells and Cancer Stem
It is pointed out that cancer stem cell is a cell type within a tumor that possesses the capacity of cell-renewal and can give rise to the heterogeneous lineages of cancer cells that comprise the tumor. It is emphasized that a cancer stem cell is a tumor
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Stem Cells and Cancer Stem Cells Volume 3
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Stem Cells and Cancer Stem Cells Volume 3
Stem Cells and Cancer Stem Cells Therapeutic Applications in Disease and Injury Edited by
M.A. Hayat Distinguished Professor Department of Biological Sciences, Kean University, Union, NJ, USA
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Editor M.A. Hayat Department of Biological Sciences Kean University Union, NJ, USA [email protected]
ISBN 978-94-007-2414-3 e-ISBN 978-94-007-2415-0 DOI 10.1007/978-94-007-2415-0 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2011933477 © Springer Science+Business Media B.V. 2012 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
“Although touched by technology, surgical pathology always has been, and remains, an art. Surgical pathologists, like all artists, depict in their artwork (surgical pathology reports) their interactions with nature: emotions, observations, and knowledge are all integrated. The resulting artwork is a poor record of complex phenomena.” Richard J. Reed MD
One Point of View
All small tumors do not always keep growing, especially small breast tumors, testicular tumors, and prostate tumors. Some small tumors may even disappear without a treatment. Indeed, because prostate tumor grows slowly, it is not unusual that a patient may die at an advanced age of some other causes, but prostate tumor is discovered in an autopsy study. In some cases of prostate tumors, the patient should be offered the option of active surveillance followed by PSA test or biopsies. Similarly, every small kidney tumor may not change or may even regress. Another example of cancer or precancer reversal is cervical cancer. Precancerous cervical cells found with Pap test, may revert to normal cells. Tumor shrinkage, regression, reversal, or stabilization is not impossible. Another known example of cancer regression is found in pediatric neuroblastoma patients. Neuroblastoma shows one of the highest rates of spontaneous regression among malignant tumors. In addition to the well-known spontaneous regression in stage 4S disease, the high incidence of neuroblastoma remnants found during autopsy of newborns suggest that localized lesions may undergo a similar regression (Guin et al., 1969). Later studies also indicate that spontaneous regression is regularly seen in infants with localized neuroblastoma and is not limited to the first year of life (Hero et al., 2008). These and other studies justify the “wait and see” strategy, avoiding chemotherapy and radiotherapy in infants with loca
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