Regulatory T cells from the inflamed joints of patients with juvenile idiopathic arthritis (JIA) are dysregulated and di
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POSTER PRESENTATION
Open Access
Regulatory T cells from the inflamed joints of patients with juvenile idiopathic arthritis (JIA) are dysregulated and display a pro-inflammatory profile AM Pesenacker*, Stavroula Zavitsanou, Kiran Nistala, Lucy R Wedderburn From 18th Pediatric Rheumatology European Society (PReS) Congress Bruges, Belgium. 14-18 September 2011 Background Regulatory T cells (Treg) are abundant in the inflamed joints of children with JIA. However the high number of Treg is not able to control the inflammation within the joint, suggesting a shortcoming of their regulatory function. It has been suggested that Treg can develop a proinflammatory profile that is specifically related to the local pro-inflammatory response. In this study we investigated whether Treg within the inflamed joint of JIA patients express pro-inflammatory markers. Aim This study examines the pro-inflammatory potential of Treg and how this might impact their regulatory function within the inflamed joint of children with JIA. Methods Peripheral blood mononuclear cells (PBMC) and synovial fluid mononuclear cells (SFMC) of 12 children with JIA were analysed by flow cytometry for Treg, their maturation and lineage markers, and cytokine production. Results In the inflamed joint of children with JIA an increase of cytokine producing Treg was observed compared to patient PBMC. A mean of 2.13% of all CD4 T cells were IFN-g and FoxP3 positive in the SFMC compared to 0.30% in the PBMC of JIA patients (p
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