Relationship between homocysteine level and diabetic retinopathy: a systematic review and meta-analysis
- PDF / 608,767 Bytes
- 9 Pages / 595.276 x 793.701 pts Page_size
- 8 Downloads / 187 Views
ORIGINAL ARTICLE
Open Access
Relationship between homocysteine level and diabetic retinopathy: a systematic review and meta-analysis Chong Xu1,2†, Yan Wu2,3†, Guodong Liu2†, Xiaoqiang Liu2, Fang Wang2* and Jing Yu2*
Abstract Background: The relationship between homocysteine (Hcy) and diabetic retinopathy (DR) remains unclear to date. Therefore, a systematic review and meta-analysis was performed on the relationship between Hcy level and DR. Methods: Studies were identified by searching PubMed, Embase, and Web of Science databases until 5 May, 2014. Results: A total of 31 studies involving 6,394 participants were included in the meta-analysis. After pooling the data from each included study, the blood Hcy concentration in the DR group was observed to be higher than that in the control group [WMD = 2.55; 95% confidence interval (CI), 1.70–3.40], and diabetes mellitus (DM) patients with hyperhomocysteinemia were at a risk for DR [odds ratio (OR) = 1.93; 95% CI, 1.46–2.53]. Considering the different DM types, hyperhomocysteinemia in T1DM (OR = 1.83, 95% CI, 1.28–2.62) was associated with DR rather than in T2DM (OR = 1.59, 95% CI, 0.72–3.51). Considerable statistical heterogeneity in the overall summary estimates was partly explained by the geographical differences. Conclusions: Results from this current meta-analysis indicate that hyperhomocysteinemia is a risk factor for DR, especially proliferative DR. Differences between geographical regions were observed in the relationship between hyperhomocysteinemia with T1DM risk. Given the heterogeneous results, the relationship between high Hcy and DR needs further investigation. Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/ vs/13000_2014_167 Keywords: Hyperhomocysteinemia, Homocysteine, Diabetic retinopathy (DR)
Background Diabetic retinopathy (DR), a common complication of diabetes, is the leading cause of low vision and blindness worldwide [1]. To date, no effective treatment has been found. Therefore, finding new risk factors and biomarkers to prevent the progression of DR is important. A number of risk factors are associated with the incidence of DR, such as blood pressure, blood glucose, glycosylated hemoglobin, blood urea nitrogen, creatinine, and β2microglobulin. However, the risk factors for DR are complicated by many aspects. * Correspondence: [email protected]; [email protected] † Equal contributors 2 Department of Ophthalmology, Shanghai Tenth People’s Hospital, Affiliate of Tongji University School of Medicine, Shanghai 200072, China Full list of author information is available at the end of the article
Homocysteine (Hcy) is a sulfur-containing amino acid formed by the demethylation of methionine; it is an emerging risk factor for diabetic nephropathy and cardiovascular disease that has gradually elicited the interest of researchers [2]. These researchers found that the level of Hcy is related to DR, especially proliferative DR [3,4]. However, studies on the relationship betwee
Data Loading...
