Relationship between serum triglyceride to high-density lipoprotein cholesterol ratio and sarcopenia occurrence rate in
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RESEARCH
Open Access
Relationship between serum triglyceride to high-density lipoprotein cholesterol ratio and sarcopenia occurrence rate in community-dwelling Chinese adults Na Wang1†, Mengjun Chen2† and Danhong Fang3*
Abstract Background: A study conducted on elderly Korean men showed that a high serum triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio was associated with a high risk of developing sarcopenia. We aimed to determine such an association in community-dwelling Chinese adults. Methods: From May 2016 to August 2017, we conducted a cross-sectional study on Chinese adults at the First Affiliated Hospital of Wenzhou Medical University. Univariate and multivariate logistic regression analyses were applied to evaluate a possible relationship between TG/HDL-C ratio and sarcopenia occurrence. Results: We included 2613 adults in this study, with 13.85% presenting with sarcopenia. The odds ratios (ORs) for TG and HDL-C were 0.67 (95% confidence interval [CI]: 0.51–0.87), and 1.97 (95% CI: 1.49–2.61), respectively. Moreover, TG/HDL-C ratio was independently associated with sarcopenia status (OR: 0.63; 95% CI: 0.49–0.81). Conclusions: We found that TG and HDL-C were, respectively, negatively and positively associated with sarcopenia occurrence rate in community-dwelling Chinese adults. However, a negative association was found between sarcopenia occurrence rate and TG/HDL-C ratio. Keywords: Sarcopenia, Triglyceride, High-density lipoprotein cholesterol, Community-dwelling Chinese adults
Introduction Sarcopenia, which was defined by the 2014 Asian Working Group for Sarcopenia (AWGS) as the agerelated reduction of muscle mass and function, has drawn public attention worldwide [1–5]. In 2019, however, the AWGS regarded possible sarcopenia as either reduced muscle strength or reduced physical ability. The global prevalence of sarcopenia, which has gradually
* Correspondence: [email protected] † Na Wang and Mengjun Chen contributed equally to this work. 3 Cardiology Department, the First Affiliated Hospital of Wenzhou Medical University, Nan Bai Xiang Street, Ouhai District, Wenzhou 325002, Zhejiang, China Full list of author information is available at the end of the article
become a public health problem, has been on the rise, and its incidence is at 5.5–25.7% [6–8]. Presently, the pathophysiology of sarcopenia remains unelucidated. Many variables, such as age, inflammation, hormonal changes, and cachexia are considered as risk factors of sarcopenia [9–15]. Serum lipid profile is commonly tested in a clinical setting. Jaekyung No et al. recently published a metaanalysis and confirmed that serum triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C) levels had a positive and negative correlation with sarcopenia, respectively [16]. Tae-Ha et al. demonstrated that a higher TG/HDL-C ratio was associated with an increased rate of sarcopenia occurrence in elderly Korean
© The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 Internation
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