Associations between serum lipoprotein(a) levels and the severities of aortic and coronary atherosclerosis
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BioMed Central
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Associations between serum lipoprotein(a) levels and the severities of aortic and coronary atherosclerosis Yukihiko Momiyama*1, Reiko Ohmori2, Zahi A Fayad3, Teruyoshi Kihara4, Ryuichi Kato2, Hiroaki Taniguchi2, Masayoshi Nagata4, Haruo Nakamura2 and Fumitaka Ohsuzu2 Address: 1National Hospital Organization Tokyo Medical Center, Tokyo, Japan, 2National Defense Medical College, Saitama, Japan, 3Mount Sinai School of Medicine, New York, NY, USA and 4Iruma Heart Hospital, Saitama, Japan * Corresponding author
from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. 21-24 January 2010 Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):P131
doi:10.1186/1532-429X-12-S1-P131
Abstracts of the 13th Annual SCMR Scientific Sessions - 2010
Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-infoThis abstract is available from: http://jcmr-online.com/content/12/S1/P131 © 2010 Momiyama et al; licensee BioMed Central Ltd.
Introduction Recently, lipoprotein(a) (Lp(a)) became recognized as a coronary risk factor. A few studies showed association between Lp(a) and thoracic aortic plaques using transesophageal echocardiography, but there was no report showing associations between Lp(a) and both thoracic and abdominal aortic plaques.
Purpose Using MRI, we investigated associations between serum Lp(a) levels and aortic atherosclerosis as well as coronary atherosclerosis.
Methods Aortic MRI was performed on Signa 1.5 T in 143 patients undergoing coronary angiography. Transverse PDW and T2W images of thoracic descending and abdominal aortas were obtained using double-inversion-recovery FSE sequence: TR = 2 RR intervals, TE = 10 ms (PDW) and 60 ms (T2W), 20-cm FOV, 4-mm slice thickness, and 8-mm inter-slice gap. For each patient, 9 slices of thoracic aorta and 9 slices of abdominal aorta were obtained at 12-mm intervals. Plaque extent in each slice was scored 0-4 points by the percentage of luminal surface involved by plaque. The severity of aortic atherosclerosis was represented as sum of scores (plaque score). On coronary angiograms, the severity of coronary atherosclerosis was represented as
the numbers of > 50% stenotic vessels and > 25% stenotic segments.
Results Of 143 patients, 104(73%) had CAD(> 50% stenosis) on angiograms. Thoracic and abdominal aortic plaques were found in 89(62%) and 131(92%) patients. Lp(a) levels were higher in patients with CAD than without CAD (median 21.8 vs. 15.7 mg/dL, P < 0.05). Stepwise increase in Lp(a) levels was found depending on the number of > 50% stenotic vessels: 15.7 (0-VD), 21.2 (1-VD), 21.4 (2VD), and 22.9 mg/dL(3-VD) (P < 0.05). Lp(a) correlated with the number of > 25% stenotic segments(r = 0.18). In multivariate analysis, Lp(a) was an independent factor for CAD. Regarding aortic atherosclerosis, 143 patients were divided into quartiles by plaque score. Stepwise increase in L
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