Reproducibility of First Pass Perfusion CMR at rest and during hyperaemia for estimation of myocardial perfusion
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BioMed Central
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Poster presentation
Reproducibility of First Pass Perfusion CMR at rest and during hyperaemia for estimation of myocardial perfusion Abdulghani M Larghat*, Aleksandra Radjenovic, Neil Maredia, John Biglands, John Greenwood and Sven Plein Address: University of Leeds, Leeds, UK * Corresponding author
from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. 21-24 January 2010 Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):P228
doi:10.1186/1532-429X-12-S1-P228
Abstracts of the 13th Annual SCMR Scientific Sessions - 2010
Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-infoThis abstract is available from: http://jcmr-online.com/content/12/S1/P228 © 2010 Larghat et al; licensee BioMed Central Ltd.
Introduction CMR has demonstrated excellent reproducibility for assessment of cardiac function, mass and volume. Reproducibility data for first-pass CMR perfusion estimates are sparse, but are important to monitor for example the response of therapies which affect myocardial blood flow.
index, MPI) using MASS 6.0 (Medis, Leiden, The Netherlands). The myocardial perfusion reserve index (MPRI) was calculated as the ratio of hyperaemic over rest MPI.
2. To compare semi-quantitative and quantitative measurements.
Data generated in MASS were imported to a Fermi Function deconvolution algorithm implemented in Matlab (The MathWorksInc, USA) [1], that provided estimates of absolute myocardial blood flow (ml/g/min) with user input to correct for baseline and timing offsets between the input and tissue response functions. All measurements were performed by one observer, who repeated analysis of the first CMR scan after 4 weeks. In addition, a second observer performed separate blinded analysis of the first study.
Methods
Results
11 volunteers (6 males, mean age 33 ± 7 years) underwent CMR perfusion on 2 separate days (mean interstudy delay = 84 ± 111 days, median delay = 7 days) on a 1.5 T Philips Intera system during adenosine-induced hyperaemia (140 mcg/kg/min, 0.05 mmol/kg Gd-DTPA) and rest. A pulse sequence optimised for acquisition of a single midventricular slice at systole was used (saturation recovery segmented gradient echo, 2 × SENSE TR/TE/flip 2.7 ms/1.0/ 15°, typical FOV 380 × 380 mm, matrix 160 × 160, slice thickness 10 mm, preparation pulse delay 150 ms, shot duration 130 ms). Endo- and epicardial contours were drawn. "Semi"-quantitative analysis calculated maximal upslopes of myocardial signal intensity of the entire slice, normalised to the LV blood-pool (Myocardial perfusion
All measurements indicated good reproducibility of global CMR perfusion estimates (Table 1). Reproducibility was highest for intraobserver followed by interobserver cmparisons especially in stress studies and was lowest for interstudy comparisons. Semiquantitative measurements were generally more reproducible than fully quantitative analysis.
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