The use of a cycle ergometer to calculate myocardial perfusion reserve with k-t sense-accelerated myocardial perfusion M
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BioMed Central
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The use of a cycle ergometer to calculate myocardial perfusion reserve with k-t sense-accelerated myocardial perfusion MR imaging at 3.0 Tesla Tim Lockie*1, Masaki Ishida1, Kapla de Silva1, Rupert Williams1, Simon Redwood1, Sebastian Kozerke1, Michael Marber1, Eike Nagel1 and Sven Plein2 Address: 1Rayne Institute, St Thomas Hospital, KCL, London, UK and 2Rayne Institute, St Thomas Hospital, KCL and Division of Cardiovascular and Neuronal Remodelling, LIGHT Institute, University of Leeds, Leeds, UK * Corresponding author
from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. 21-24 January 2010 Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):P87
doi:10.1186/1532-429X-12-S1-P87
Abstracts of the 13th Annual SCMR Scientific Sessions - 2010
Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-infoThis abstract is available from: http://jcmr-online.com/content/12/S1/P87 © 2010 Lockie et al; licensee BioMed Central Ltd.
Background Exercise induced stress testing is important to determine the physiological reserve of the myocardium. High heart rate (HR) and respiratory motion represent a challenge for CMR perfusion imaging requiring very fast data acquisition to minimise artefacts.
Purpose To quantify perfusion at rest and exercise-induced stress in volunteers using k-space and time sensitivity encoding (kt SENSE) CMR perfusion.
Subjects 5 volunteers (age 21-35 years) with no history of cardiac disease. Exercise protocol A specially adapted supine cycle ergometer was used and attached to the sliding table inside the CMR scanner such that the subject could exercise without leaving the table. A standardised exercise protocol was used with increments of 20 W each minute for 6 minutes at a rate of 60 rpm. Rate pressure product (RPP) calculated as peak systolic blood pressure × peak HR was recorded at peak exercise.
Methods CMR k-t SENSE accelerated perfusion CMR was performed on a 3 T Philips Achieva® system using 0.025 mmol/kg/min Gd-DO3A-butrol and the following pulse sequence: saturation recovery gradient echo, repetition time/echo time 3.0 ms/1.0 ms, flip angle 15°, 5× k-t SENSE acceleration, 11 interleaved training profiles, WET pre-pulse (angles 120°, 90°, 180°, 140°); delay 100 ms, spatial resolution 1.8 × 1.8 × 10 mm3, 3 slices at each RR interval, 40 dynamic images. For blood pool saturation correction MR images with diluted Gd-DO3A-butrol injection (0.0025 mmol/kg) were also acquired.
Analysis The mid-slice was used in each subject for further analysis. After correcting saturation of the blood signal, arterial input and myocardial output time-intensity curves were analyzed with a Patlak plot method to quantify global myocardial K1 at rest and stress. Then, absolute global myocardial blood flow (MBF) at rest and stress and perfusion reserve were calculated from K1 by using extraction fraction of Gd co
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