Research Development on Vanadium-Dependent Haloperoxidases in Marine Algae
The halogenated marine natural products encompass a very wide range of compounds which often have important biological activities or pharmacological properties. The haloperoxidases are thought to be involved in the biosynthesis of these natural products.
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Research Development on VanadiumDependent Haloperoxidases in Marine Algae Tao Wang, Yong-chao Lu, Dong-mei Cao, Shu-bao Gao and Yu-shan Zhang
Abstract The halogenated marine natural products encompass a very wide range of compounds which often have important biological activities or pharmacological properties. The haloperoxidases are thought to be involved in the biosynthesis of these natural products. A new kind of haloperoxidases that contain vanadium in the active site capable of catalyzing halogenation reactions of several substrates have been subsequently isolated from a variety of organisms, particularly in marine algae. Due to their highly chemical and thermal stability, the vanadiumdependent haloperoxidases (vHPOs) attracted more attention in the last few years. The paper mainly contemplates on the types, biological properties, and molecular structures of marine algae vHPOs as well as their biochemical function and potential industrial applications.
Keywords Biologic halogenation Halogenated products Vanadium-dependent haloperoxidases
Marine algae
T. Wang (&) Y. Lu D. Cao S. Gao Y. Zhang Department of Utilizing Chemical Resource from Seawater, National Engineering Research Centre for Seawater Utilization, Institute of Seawater Desalination and Multipurpose Utilization (SOA), Tianjin 300192, People’s Republic of China e-mail: [email protected] T. Wang Key Laboratory of Industrial Fermentation Microbiology, Tianjin University of Science & Technology, Ministry of Education, Tianjin 300457, People’s Republic of China T. Wang Tianjin Key Lab of Industrial Microbiology, Tianjin University of Science and Technology, Tianjin 300457, People’s Republic of China
T.-C. Zhang et al. (eds.), Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012), Lecture Notes in Electrical Engineering 251, DOI: 10.1007/978-3-642-37925-3_187, Ó Springer-Verlag Berlin Heidelberg 2014
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187.1 Introduction Many marine organisms, particularly the macroalgae, are frequently proved to have developed means to incorporate halogens into their metabolites that are mainly involved in antioxidants to reduce the environmental oxidative stress and chemical defenses to against opportunistic bacteria and predators [1, 2]. These halogenated compounds span a very large range from simple volatile halohydrocarbons (e.g., bromoform-, dibromomethane, methyl iodide, bromo- and chloroanisoles, etc.) to halogenated phenolic derivatives (e.g., indoles, terpenes, acetogenins, phenols, etc.) [3–6]. Since, in many cases, these halogenated marine metabolites have been found to possess biological activities of pharmacological interests, including antifungal, antibacterial, antiviral, and anti-inflammatory activities [7], the pathway of biogenesis of these compounds has intrigued marine chemists for decades. Early on turn of the twentieth century, certain enzyme activities relative to the transformation of bromine and iodine in marine algae have been initially well documented [8, 9]. K
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