Research Methodology Evaluating Complementary and Alternative Therapies
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Research Methodology: Evaluating Complementary and Alternative Therapies Carmen Tamayo, Heather Boon, Fayez Ghishan and Kien Trinh Drug Information Journal 2002 36: 535 DOI: 10.1177/009286150203600308 The online version of this article can be found at: http://dij.sagepub.com/content/36/3/535
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Drug Information luurfma[. Vol. 36, pp. 535-548, 2002 Printed in the USA. All rights reserved.
0092-8615/2002 Copyright 0 2002 Drug Information Association lnc.
RESEARCH METHODOLOGY EVALUATING COMPLEMENTARY AND ALTERNATIVE THERAPIES CARMEN TAMAYO, MD Director, Division of Complementary & Alternative Medicine, Foresight Links Corporation, London, Ontario, Canada
HEATHER BOON,BSCPHM,PHD Assistant Professor, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
FAYEZ GHISHAN, MD Professor of Pediatrics and Physiology, and Head, Department of Pediatrics, University of Arizona Health Sciences Center, and Director, Steele Memorial Children's Research Center, Tucson, Arizona
KIENTRINH,MD, BSc, MSc Assistant Clinical Professor, McMaster University, and Program Chair, Medical Acupuncture. McMaster University Health Sciences, Hamilton, Ontario, Canada
Complementap and alternative medicine (CAM) represents an opportunity YO expand tools for assisting patients with health care issues, retain or increase market share by proactively responding to consumers, and increase our understanding of interventions outside of conventional medicine. CAM research is a flourishing area that is currently receiving a new focus as a result of the creation of recognized CAM research centers in university settings worldwide. Several botanical products, complex CAM interventions and individual approaches are now being tested with rigorous and well-controlled research. Adequate execution of clinical trials, howevez represents a major challenge, particularly in medical fields such as pediatrics and CAM therapies such as acupuncture and herbal medicine. The scientific community, industry, and consumers are joining efforts to provide reliable and objective information about the efJicacy and safe8 of CAM therapies. Medical journals are publishing CAM-related issues regularly and there is concern about quality of clinical trials, reliabilitv of results, placebo effect, and publication bias. The number of CAM clinical trials continues to grow although it is still vety low compared with conventional medicine trials. There are major research methodology issues that need to
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