Restoring Function to the Injured Human Spinal Cord
Of catastrophic traumas to the human body, spinal cord injury (SCI) has least benefited from innovations arising from the new biology. Since after WW II, the "standard of care" for SCI has changed little. The controversial use of high dosages of st
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Vol. 171
Editors F. Beck, Melbourne B. Christ, Freiburg W. Kriz, Heidelberg W. Kummer, GieBen E. Marani, Leiden R. Putz, Munchen Y. Sano, Kyoto T. H. Schiebler, Wurzburg K. Zilles, Dusseldorf
Springer Berlin Heidelberg New York Hong Kong London Milan Paris Tokyo
Richard Ben Borgens
Restoring Function to the Injured Human Spinal Cord
With 32 Figures
Springer
Richard Ben Borgens Mari Hulman George Professor of Applied Neurology, School of Veterinary Medicine Professor of Biomedical Engineering, School of Engineering Purdue University, 408 S. University Street West Lafayette, Indiana 47907-2096 USA e-mail: [email protected]
ISSN 0301-5556 ISBN-13:978-3-540-44367-4 e-ISBN-13:978-3-642-59361-1 DOl: 10.1007/978-3-642-59361-1 Springer-Verlag Berlin Heidelberg New York This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9,1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer-Verlag a member of BertelsmannSpringer Science + Business Media GmbH http://www.springer.de © Springer-Verlag Berlin Heidelberg 2003
The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Typesetting: Stiirtz, Wiirzburg Printed on acid-free paper
27/3150Ag-5 4 3 2 1 0
Restoring Function to the Injured Human Spinal Cord
Richard Ben Borgens Mari Hulman George Professor of Applied Neurology, School of Veterinary Medicine Professor of Biomedical Engineering, School of Engineering Purdue University, West Lafayette, Indiana 47907, USA (765) 494-7600 Fax: (765) 494-7605 e-mail: [email protected]
Illustrator:
Kimberly J. Harrington Center for Paralysis Research, Department of Basic Medical Sciences School of Veterinary Medicine Purdue University, West Lafayette, Indiana 47907, USA
I dedicate this Book to the Memory of Melvin Cohen Professor of Biology Yale University Professor Cohen taught me to dream with optimism about the potential for the New Biology to change the quality of lives ofparalyzed people But through hard work and careful experimentation He will be greatly missed
Acknowledgements
This text describes many experiments and clinical trials, none of which would be possible without the dedication and esprit de c
