Retinal image measurements and their association with chronic kidney disease in Chinese patients with type 2 diabetes: t
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ORIGINAL ARTICLE
Retinal image measurements and their association with chronic kidney disease in Chinese patients with type 2 diabetes: the NCD study Xiayu Xu1,2 · Bin Gao3 · Wenxiang Ding1,2 · Qiong Wang4 · Maiye Zhang4 · Tao Tan5 · Fei Sun4 · Jianqin Lei6 · Qiuhe Ji4 · Feng Xu1,2 Received: 15 June 2020 / Accepted: 12 October 2020 © Springer-Verlag Italia S.r.l., part of Springer Nature 2020
Abstract Aims Retinal and renal microcirculations are known to share similar physiological changes during early diabetes because of abnormal glucose metabolism and other processes. The retinal vasculature therefore may serve as potential biomarker for the early identification of those at high risk of chronic kidney disease (CKD) in diabetes. Methods Data from 1925 patients (aged 49.0 ± 10.3) with type 2 diabetes were analyzed. Various retinal image measurements (RIMs) were collected using a validated fully automated computer program. Multiple logistic regressions were performed to investigate the correlation between RIMs and CKD. Results In logistic regression adjusting for multiple variables, wider venular calibers in the central and middle zones and narrower arteriolar caliber in the central zone were associated with CKD (p
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