Reversal of Coagulopathy Using Prothrombin Complex Concentrates is Associated with Improved Outcome Compared to Fresh Fr

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ORIGINAL ARTICLE

Reversal of Coagulopathy Using Prothrombin Complex Concentrates is Associated with Improved Outcome Compared to Fresh Frozen Plasma in Warfarin-Associated Intracranial Hemorrhage Jennifer A. Frontera • Errol Gordon • Victor Zach • Maximo Jovine Ken Uchino • Muhammad S. Hussain • Louis Aledort



Ó Springer Science+Business Media New York 2014

Abstract Background There are no studies demonstrating that prothrombin complex concentrates (PCC) improves outcome compared FFP in patients with warfarin-associated intracranial hemorrhage. Methods A prospective, observational study was conducted of patients who received PCC (Bebulin VH), FFP, or PCC + FFP. All groups received vitamin K 10 mg IV. INR reversal (