Rheumatoid Arthritis Recent Research Advances
Many advances have occurred in the last 5 years especially in understanding genetic susceptibility factors, the role of immune response in chronic arthritis and the relationship between cellular processes that underlie inflammation and tissue damage. All
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Rheumatoid Arthritis Recent Research Advances
With 53 Figures and 58 Tables
Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest
Professor Dr. Josef S. Smolen 2. Medizinische Abteilung Zentrum fUr Diagnostik und Therapie rheumatischer Erkrankungen Krankenhaus der Stadt Wien-Lainz und Ludwig Boltzmann Institut fUr Rheumatologie und Balneologie WolkersbergenstraBe 1, A-ll30 Wien, Austria Professor Dr. Joachim R. Kalden Medizinische Klinik III mit Poliklinik und Institut fUr Klinische Immunologie und Rheumatologie Friedrich-Alexander-U niversitat Erlangen-N urnberg KrankenhausstraBe 12, W-8520 Erlangen Federal Republic of Germany Professor Dr. Ravinder N. Maini Mathilda and Terence Kennedy Institute of Rheumatology 6 Bute Gardens, Hammersmith London W6 7DW, United Kingdom
Library of Congress Cataloging-in-Publication Data Rheumatoid arthritis: recent research advances / J. S. Smolen, J. R. Kalden, R. N. Maini (eds.). p. cm. Includes bibliographical references and index. ISBN-13: 978-3-642-76191-1 e-ISBN-13: 978-3-642-76189-8 DOl: 10.1007/978-3-642-76189-8
I. Rheumatoid arthritis. I. Smolen, Josef S., 1950- . II. Kalden, J. R. (Joachim Robert) III. Maini, R. N. [DNLM: 1. Arthritis, Rheumatoid. WE 346 R47307] RC933.R4288 616.7'227--dc20 DLC for Library of Congress 91-5068 CIP
1992
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Preface
Clinical medicine first recognized rheumatoid arthritis (RA) as a disease entity in the nineteenth century. In the early days the major development in understanding this disease came at the bedside, in distinguishing it from rheumatic fever and gout. Later, with the advances in medicine and the powerful ideas emanating from the fastgrowing fields of pathology and microbiology, interest turned to the descri
