Maternal circulating levels of some metabolic syndrome biomarkers in gestational diabetes mellitus
- PDF / 1,251,806 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 92 Downloads / 171 Views
ORIGINAL ARTICLE
Maternal circulating levels of some metabolic syndrome biomarkers in gestational diabetes mellitus Ali Khosrowbeygi1,2 • Najmeh Shiamizadeh1 • Nima Taghizadeh1
Received: 17 March 2015 / Accepted: 18 July 2015 Ó Springer Science+Business Media New York 2015
Abstract The aims of the present study were to explore serum levels of lipid profile, atherogenic indexes LDL-C/ HDL-C, TG/HDL-C, and TC/HDL-C, bilirubin, adiponectin, pseudocholinesterase, activities of gamma-glutamyltransferase (GGT), adenosine deaminase (ADA), and a-amylase, insulin resistance using homeostasis model assessment of insulin resistance (HOMA-IR) formula, and assessment of correlations between them in gestational diabetes mellitus (GDM) compared with normal pregnancy. A cross-sectional study was designed. The patients consisted of 30 women with GDM. The normal group consisted of 30 healthy pregnant women. The Mann– Whitney U test and Spearman’s correlation analysis were used for statistical analysis. A p value less than 0.05 was considered significant. Serum activities of enzymes GGT (p = 0.001) and ADA (p = 0.02) were significantly higher in GDM compared with normal pregnancy, while pseudocholinesterase were significantly decreased (p = 0.02). However, activity of enzyme a-amylase did not show significant difference between two groups (p = 0.75). Serum levels of both HDL-C and adiponectin were significantly decreased in GDM group (p = 0.001). The atherogenic indexes and the HOMA-IR index were significantly higher in GDM (p = 0.001). Serum activity of ADA showed positive correlation with total cholesterol (TC) (r = 0.46, p = 0.01) and CRP (r = 0.66, p = 0.001) in GDM group. Serum levels of total bilirubin correlated & Ali Khosrowbeygi [email protected]; [email protected] 1
School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
2
Department of Biochemistry, School of Medicine, Arak University of Medical Sciences, Arak, Iran
negatively with both ADA (r = -0.38, p = 0.04) and triglyceride (r = -0.45, p = 0.01) in women with GDM. Serum activity of GGT correlated positively with LDL-C (r = 0.48, p = 0.01) and TC (r = 0.52, p = 0.003) in GDM group. Increased atherogenic indexes, ADA, GGT, and decreased pseudocholinesterase might be risk factors for GDM. Keywords Adenosine deaminase Amylase Atherogenic index Gamma-glutamyltransferase Insulin resistance Gestational diabetes mellitus
Introduction Gestational diabetes mellitus (GDM) is defined as any degrees of impaired glucose tolerance that first appears or is recognized during pregnancy. The prevalence of GDM ranged from 1 to 15 % in all pregnancies depending on the ethnic group studied and diagnostic criteria employed [1, 2]. It has been shown that low serum a-amylase activity is associated with prevalence of metabolic syndrome [3], diabetes [4, 5], and non-alcoholic fatty liver [6] but little data are available in the patients with GDM. There are some conflicting findings of maternal circulating levels of lipids in women with GDM
Data Loading...
