Role of Canonical and Non-canonical Inflammasomes During Burkholderia Infection
Burkholderia pseudomallei is a Gram-negative flagellate bacterium that causes melioidosis, a disease endemic to Southeast Asia and other tropical regions. Following infection of macrophages and other non-phagocytic cell types, B. pseudomallei or B. thaila
- PDF / 270,414 Bytes
- 16 Pages / 439.37 x 666.142 pts Page_size
- 43 Downloads / 247 Views
Abstract Burkholderia pseudomallei is a Gram-negative flagellate bacterium that causes melioidosis, a disease endemic to Southeast Asia and other tropical regions. Following infection of macrophages and other non-phagocytic cell types, B. pseudomallei or B. thailandensis (a related species that causes disease in mice but not humans) are able to escape the phagosome and replicate in the host cell cytoplasm. Resistance to infection with Burkholderia is dependent on the Nlrp3 and Nlrc4 inflammasomes and the non-canonical caspase-11 inflammasome. Nlrc4 mediates protection through induction of pyroptosis in the early phase of infection. As the infection progresses and as IL-18-dependent IFNc production increases, caspase-11-dependent pyroptosis acquires a preponderant protective role. Production of IL-1b and IL-18 during infection is primarily mediated by Nlrp3. IL-18 is essential for survival because of its ability to induce IFNc production, which in turn activates macrophage microbicidal functions and primes for caspase-11 expression. In contrast, during melioidosis, IL-1b has deleterious effects due to excessive recruitment of neutrophils to the lung and consequent tissue damage.
Contents 1 2 3 4 5 6
Introduction........................................................................................................................ Innate Immune Response to Burkholderia Infection........................................................ Role of Caspase-1 ............................................................................................................. Role of NLRC4 Inflammasome ........................................................................................ Role of NLRP3 Inflammasome......................................................................................... Opposing Function of IL-1b and IL-18............................................................................
200 201 202 202 203 204
M. Sahoo L. Lantier F. Re (&) Department of Microbiology & Immunology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA e-mail: [email protected] © Springer International Publishing Switzerland 2016 S. Backert (ed.), Inflammasome Signaling and Bacterial Infections, Current Topics in Microbiology and Immunology 397, DOI 10.1007/978-3-319-41171-2_10
199
200 7 8 9 10
M. Sahoo et al. Role of the Caspase-11 Non-canonical Inflammasome.................................................... Different Contribution of the Canonical and Non-canonical Inflammasomes ................. Role of the Human Non-canonical Inflammasome .......................................................... Concluding Remarks .........................................................................................................
206 207 209 209
References .................................................................................................................................. 210
1 Introduction Burkholderia pseudomallei is a Gram-negative, rod-shap
Data Loading...
