Role of chromatin assembly factor-1/p60 and poly [ADP-ribose] polymerase 1 in mycosis fungoides
- PDF / 572,162 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 3 Downloads / 177 Views
ORIGINAL ARTICLE
Role of chromatin assembly factor-1/p60 and poly [ADP-ribose] polymerase 1 in mycosis fungoides Massimo Mascolo 1 & Antonio Travaglino 1 & Silvia Varricchio 1 & Daniela Russo 1 & Elena Sabattini 2 & Claudio Agostinelli 2 & Clara Bertuzzi 2 & Antonello Baldo 3 & Alessandro Pileri 4 & Marco Picardi 5 & Fabrizio Pane 5 & Stefania Staibano 1 Received: 30 July 2020 / Revised: 16 September 2020 / Accepted: 14 October 2020 # The Author(s) 2020
Abstract Mycosis fungoides (MF) represents the most common type of cutaneous lymphoma. In the majority of patients, the disease has a slow evolution and a protracted course; however, a subset of patients shows poor oncologic outcomes. Unfortunately, there are no reliable prognostic markers for MF, and the currently available treatments are only effective in a minority of patients. This study aimed to evaluate the expression and clinical significance of PARP-1 and CAF-1/p60 in MF. Sixty-four MF representatives of the different stages of disease were assessed by immunohistochemistry for PARP-1 and CAF-1/p60. The association of PARP-1 and CAF-1/p60 with the MF stage and outcome was assessed by using Fisher’s exact test and Kaplan-Meier survival analysis with the Log-rank test; a p value < 0.05 was considered significant. PARP-1 was overexpressed in 57.9% of MF and was significantly associated with a MF stage > II (p = 0.034) but not with the risk of death (p = 0.237). CAF-1/p60 was overexpressed in 26.8% of MF and was significantly associated with decreased overall survival (p < 0.001) but not with the MF stage (p = 1). A significant association was found between PARP-1 overexpression and CAF-1/p60 overexpression (p = 0.0025). Simultaneous overexpression of PARP-1 and CAF-1/p60 was significantly associated with decreased overall survival (p < 0.001), although less strongly than CAF-1/p60 alone (χ2 = 14.916 vs 21.729, respectively). In MF, PARP-1 is overexpressed in advanced stages, while CAF-1/p60 is overexpressed in the cases with shorter overall survival, appearing as a significant prognostic marker. A role for PARP-1 inhibitors and anti-CAF-1/p60 targeted therapy may be reasonably hypothesized in MF. Keywords Mycosis fungoides . Cutaneous lymphoma . Poly [ADP-ribose] polymerase 1 . Chromatin assembly factor-1 . Prognosis Antonio Travaglino and Silvia Varricchio contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00428-020-02952-z) contains supplementary material, which is available to authorized users. * Massimo Mascolo [email protected] 1
Department of Advanced Biomedical Sciences, Pathology Section, School of Medicine, University of Naples “Federico II”, Via Sergio Pansini, 5, 80131 Naples, Italy
2
Haematopathology Unit, Department of Experimental Diagnostic and Specialty Medicine, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
3
Department of Clinical Medicine and Surgery, Dermatology Section, University of Naples “Federico II”, Naples, Italy
4
Dermato
Data Loading...
