Role of Fibronectin-1 polymorphism genes with the pathogenesis of intraventricular hemorrhage in preterm infants
- PDF / 276,013 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 24 Downloads / 157 Views
ORIGINAL ARTICLE
Role of Fibronectin-1 polymorphism genes with the pathogenesis of intraventricular hemorrhage in preterm infants Dawid Szpecht 1 & Salwan R. Al-Saad 2 & Lukasz M. Karbowski 2 & Katarzyna Kosik 1 & Grażyna Kurzawińska 3 & Marta Szymankiewicz 1 & Krzysztof Drews 3 & Agnieszka Seremak-Mrozikiewicz 3 Received: 20 January 2020 / Accepted: 27 March 2020 # The Author(s) 2020
Abstract Background/introduction Intraventricular hemorrhage (IVH) is a dangerous complication facing a significant proportion of preterm infants. It is multifactorial in nature, and an observed fibronectin deficiency in the germinal matrix basal lamina is among the most prominent factors that influence such rupture. Better understanding of the FN1 gene polymorphisms and their role in IVH may further clarify the presence of a genetic susceptibility of certain babies to this complication. The aim of this study was to assess if 5 single nucleotide polymorphisms of the fibronectin gene may be linked to an increased incidence of IVH. Material and methods The study included 108 infants born between 24 and 32 weeks of gestation. IVH was diagnosed using cranial ultrasound performed on the 1st,3rd, and 7th day after birth and classified according to Papile et al. IVH classification. The 5 FN1 gene polymorphisms assessed in the study were the following: rs3796123; rs1968510; rs10202709; rs6725958; and rs35343655. Results IVH developed in 51 (47.2%) out of the 108 preterm infants. This includes, 18 (35.3%) with stage I IVH, 19 (37.3%) with stage II, 11 (21.6%) with stage III, and 3 (5.9%) with stage IV IVH. Incidence of IVH was higher in infants with lower APGAR scores, low gestational age, and low birthweight. Analysis showed that IVH stage II to IV was approximately seven times more likely to occur in infants with the genotype TT FN1 rs10202709 (OR 7237 (1046–79.59; p = 0,044)). No other significant association was found with the rest of the polymorphisms. Conclusion The results of our study indicate a sevenfold increased genetic susceptibility to IVH in preterm infants with the TT FN1 rs10202709 gene polymorphism. The fibronectin gene polymorphism may therefore be of crucial importance as a genetic risk factor for IVH in preterm infants. Further studies are warranted. Keywords Fibronectin-1 . Polymorphism genes . Intraventricular hemorrhage . Preterm infants
Introduction Intraventricular hemorrhage (IVH) is one of the most severe complications of preterm birth. In some cases, it may lead to Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00381-020-04598-3) contains supplementary material, which is available to authorized users. * Dawid Szpecht [email protected] 1
Chair and Department of Neonatology, Poznan University of Medical Sciences, Poznan, Poland
2
Poznan University of Medical Sciences, Poznan, Poland
3
Department of Perinatology and Women’s Diseases, Poznan University of Medical Sciences, Poznan, Poland
death, and on the other hand a significant proportion of preterm infant
Data Loading...
