Role of HLA-DRB1*04 in the susceptibility and HLA-DRB1*08 in the protection for development of rheumatoid arthritis in a
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BRIEF REPORT
Role of HLA-DRB1*04 in the susceptibility and HLA-DRB1*08 in the protection for development of rheumatoid arthritis in a population of Southern Mexico: brief report J. Sepúlveda-Delgado 1,2,3 & A. Rizo-Pinto 4,5 & J. Granados-Arriola 6 & B. A. Mena-Vela 4 & J. H. Cetina-Díaz 4 R. García-Silva 6 & S. Hernández-Doño 6 & M. A. Cruz-Salvatierra 4 & J. M. Pérez-Tirado 7 & C. Vázquez-Guzmán 4 & S. Dominguez-Arrevillaga 8 & M. G. Trujillo-Vizuet 8 & R. A. Sanchez-González 8 & F. Zamudio-Castellanos 8 & O. L. Vera-Lastra 9 & L. J. Jara-Quezada 9
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Received: 29 December 2019 / Revised: 11 March 2020 / Accepted: 20 March 2020 # International League of Associations for Rheumatology (ILAR) 2020
Abstract Rheumatoid arthritis (RA) is an autoimmune inflammatory disease with an increased prevalence in Mexico. Although its etiology is unknown, its development can be influenced by environmental factors such as smoking and viral infections. But among the factors influencing susceptibility, it is the genetic factors that predominate, mainly the HLA-DRB1 genes, and specifically the alleles that have the shared epitope (SE). A transversal study was performed, in which 31 patients (28 women and 3 men) with RA, treated at the autoimmunity clinic of the High Specialty Hospital Ciudad Salud in Tapachula, Chiapas, southern México, were enrolled. Clinical, biochemical, and demographic data were analyzed; ESR (erythrocyte sedimentation rate), CRP (Creactive protein), RF (rheumatoid factor), and ACPA (anticitrullinated peptide antibody) were recorded. All patients had at least one positive RA biological marker. For HLA alleles frequencies comparison, we enrolled ethnically matched healthy controls in a ratio of 3:1 for 25 cases and 4:1 for 6 cases in order to guarantee the balance between groups regarding the mean of age and proportion of gender (males vs females). HLA-DRB1*04 was found to be significantly increased in patients compared with ethnically matched healthy controls (p 0.0007, OR: 2.8, 95% CI 1.5–5.1); contrarily, DRB1*08 showed a protective effect (p 0.005, OR 0.1). This paper confirmed the involvement of HLA genes on risk determination for RA in a population of Mexican Mestizos from Tapachula, Chiapas. Key Points • HLA-DRB1*04 confirms the increased risk of rheumatoid arthritis. • HLA-DRB1*08 showed a more definite protective effect in southern Mexicans mestizos, a population with more Amerindian ancestry.
Keywords HLA-DRB1 antigen . Rheumatoid arthritis . Shared epitope . Viral infections
* J. Sepúlveda-Delgado [email protected]
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Centro Universitario Cultural del Soconusco, Tapachula, Chiapas, Mexico
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División de Inmunogénetica, Departamento de Trasplante, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, Mexico
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Hospital Regional de Alta Especialidad Ciudad Salud, Tapachula, Mexico
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Research and Diagnosis Division, Hospital Regional de Alta Especialidad Ciudad Salud, Tapachula, Mexico
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Hospital General de Zona No. 1, Instituto Mexicano del Seguro Social, Tap
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