Role of Kinetic Models in Drug Stability

Kinetic models are studied to determine their role in stability and release kinetics of drugs. The mathematical models that have been widely used are zero-order kinetic model, first-order kinetic model, Higuchi model, Korsmeyer-Peppas model, and Hixson-Cr

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Stability and Chemical Kinetics

Drug Stability and Chemical Kinetics

Muhammad Sajid Hamid Akash • Kanwal Rehman Editors

Drug Stability and Chemical Kinetics

Editors Muhammad Sajid Hamid Akash Department of Pharmaceutical Chemistry Government College University Faisalabad, Pakistan

Kanwal Rehman Department of Pharmacy University of Agriculture Faisalabad, Pakistan

ISBN 978-981-15-6425-3 ISBN 978-981-15-6426-0 https://doi.org/10.1007/978-981-15-6426-0

(eBook)

# The Editor(s) (if applicable) and The Author(s), under exclusive licence to Springer Nature Singapore Pte Ltd. 2020 This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore

This book is dedicated to Our Beloved and Adorable Little Twinkles Muhammad Aqdas Akash & Zainab Akash

Preface

Stability studies are essential for certifying safety, efficacy and quality of drug products to assess their shelf life. These studies assure that pharmaceutical products will exhibit constant efficacy under specified storage conditions. Developments in pharmaceutical industry show novel ways for preserving the quality of pharmaceutical preparations. Stability is vital for protection, value and quality of a drug. The investigation of drug stability is essential to improve quality, safety and efficacy. Drug toxicity and its adverse effects can be prevented by evaluating parameters related to stability. Upon storage, pharmaceutical products are vulnerable to chemical and physical degradation. These degradations alter pharmacological properties of a drug resulting in reduced benefits and increased toxicity. Physical factors that influence the stability of pharmaceuticals are heat, ionic strength, acid-base cataly

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