Role of PAX-7 as a tissue marker in mangled extremity: a pilot study
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ORIGINAL ARTICLE • TRAUMA - INFECTION
Role of PAX‑7 as a tissue marker in mangled extremity: a pilot study Rohit Kansal1 · Rajendra Kumar Kanojia1 · Vishal Kumar1 · Kim Vaiphei2 · Mandeep Singh Dhillon1 Received: 28 November 2018 / Accepted: 1 March 2019 © Springer-Verlag France SAS, part of Springer Nature 2019
Abstract The rising incidence of mangled extremity seen in modern trauma has lead to significant patient mortality. A lot of research is going on at microcellular level for a better understanding of tissue injury, repair and regeneration. PAX-7 is one such transcription factor, a marker of satellite stem cells in skeletal muscle. Though few studies have shown concrete evidence of increased expression of PAX-7 in the nearby injured zone in skeletal muscle post-injury, none has studied its expression in an event of mangled injury of limb in humans. We, hereby, attempted to identify whether PAX-7 expression of tissue near the zone of injury, after grievous trauma like mangled injury of extremities, actually increases, decreases or remains unaffected. A pilot study was conducted on 30 cases at a level 3 trauma centre; patients were segregated into two groups—group I with MESS score ≥ 7 and group II with score
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