Rosiglitazone Ameliorates Diabetic Nephropathy by Reducing the Expression of Chemerin and ChemR23 in the Kidney of Strep
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Rosiglitazone Ameliorates Diabetic Nephropathy by Reducing the Expression of Chemerin and ChemR23 in the Kidney of Streptozotocin-Induced Diabetic Rats Wenchao Hu,1 Qian Yu,2 Jie Zhang,2 and Demin Liu2,3
Abstract—Chemerin is shown to be associated with inflammation which is involved in the pathogenesis of diabetic nephropathy. This study aims to determine whether rosiglitazone and pioglitazone ameliorate renal function through an effect on the expression of chemerin and ChemR23 in streptozotocin-induced diabetic rats. The rats were randomized to control, diabetic, rosiglitazone-, and pioglitazone-treated groups. The expression level of chemerin and ChemR23 in the renal tissues was significantly elevated in the diabetic group compared with the control group. Rosiglitazone inhibited the overexpression of chemerin and ChemR23, while pioglitazone inhibited the overexpression of ChemR23 in the kidney of diabetic rats. In addition, chemerin expression level was positively correlated with transforming growth factor-β1, connective tissue growth factor, tumor necrosis factor-α, and intracellular cell adhesion molecule-1 expression in diabetic rats. Rosiglitazone ameliorates diabetic nephropathy by reducing the expression of chemerin and ChemR23 in diabetic rats. KEY WORDS: chemerin; ChemR23; diabetic nephropathy; rosiglitazone; pioglitazone; inflammation.
INTRODUCTION Diabetic nephropathy (DN) is one of the important microvascular complications of diabetes mellitus. The pathological changes such as expansion of mesangial cells, accumulation of extracellular matrix protein, thickening of glomerular and tubular basement membranes, tubulointerstitial fibrosis, glomerulosclerosis, and renal endothelial dysfunction are noted to occur in the diabetic kidney [1]. Currently, there is no specific therapy for this condition, which almost invariably progresses to end-stage renal failure. Serum chemerin was associated with renal function [2, 3]. A previous study demonstrated that serum Wenchao Hu and Qian Yu contributed equally to this article. 1
Department of Metabolism, General Hospital, Tianjin Medical University, Tianjin, People’s Republic of China 2 Department of Laboratory, Metabolic Disease Hospital, Tianjin Medical University, 66 Tong’an Street, Heping District, 300070 Tianjin, People’s Republic of China 3 To whom correspondence should be addressed at Department of Laboratory, Metabolic Disease Hospital, Tianjin Medical University, 66 Tong’an Street, Heping District, 300070 Tianjin, People’s Republic of China. E-mail: [email protected]
chemerin levels were significantly elevated in type 2 diabetic patients with macroalbuminuria compared with control subjects and diabetic patients with normoalbuminuria and microalbuminuria [4]. Chemerin was shown to be associated with inflammatory factors including high sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-α [5, 6]. Inflammatory factors have been shown to be involved in the progression of DN [7]. Chemerin expression was hypothesized to be elevated in DN. Chemerin has
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