Resveratrol prevents diabetic nephropathy by reducing chronic inflammation and improving the blood glucose memory effect
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ORIGINAL ARTICLE
Resveratrol prevents diabetic nephropathy by reducing chronic inflammation and improving the blood glucose memory effect in non-obese diabetic mice Yuxin Xian 1 & Yanyan Gao 1 & Wenshan Lv 1 & Xiaolong Ma 2 & Jianxia Hu 3 & Jingwei Chi 3 & Wei Wang 4 & Yangang Wang 1 Received: 8 September 2019 / Accepted: 12 November 2019 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Chronic inflammation plays an important role in the development of diabetic nephropathy. Advanced glycation end product receptor (RAGE), nuclear factor kappa B (NF-κB) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) are involved in the development of inflammation. Resveratrol is a plant antitoxin; it is believed to have anti-inflammatory effects and can improve blood glucose. We speculate that resveratrol treatment can protect renal function by reducing blood glucose, decreasing the expression of inflammatory factors. Non-obese diabetic (NOD) mice were randomly divided into three groups: T1DM, insulin (INS) and resveratrol (Res) groups. Mice without diabetes were classified as the non-diabetic control group (NOD-C group). The blood glucose (BG) level, blood urea nitrogen (BUN) level, serum creatinine (SCr) level and 24-h urinary microalbumin quantitative (UMA) were measured. The glomerulosclerosis index and basement membrane thickness were calculated under light and electron microscopes. The expression levels of RAGE, NF-кB (P65) and NOX4 in renal tissues were detected by Western blot analysis. We found that resveratrol treatment significantly reduced blood glucose within 28 days of the experiment, but the hypoglycemic effect was not lasting. At the same time, resveratrol reduced BUN, SCr, 24 h UMA and the expression of the inflammatory factors RAGE, NF-кB (P65) and NOX4 and improved the renal pathological structure. We believe that resveratrol improves renal function not only by its anti-inflammatory effect but also by improving the metabolic memory of hyperglycemia. Keywords Resveratrol . Diabetic nephropathy . Metabolic memory effect
Abbreviations DM Diabetes mellitus IDF The International Diabetes Federation DN Diabetic nephropathy
* Wei Wang [email protected] Yangang Wang [email protected] 1
Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao 266003, China
2
Department of Endocrinology, Liaocheng City People’s Hospital, Liaocheng, Shandong, China
3
The Lab of Thyroid Disease, The Affiliated Hospital of Qingdao University, Qingdao 266003, China
4
Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China
RAGE AGEs NF-кB MCP-1 ICAM-1 VCAM-1 NOX4 NOD UMA PAS TEM GSI GBMT
Receptor for advanced glycation end products Advanced glycation end products Nuclear factor-kappa B Monocyte chemoattractant factor-1 Intercellular cell adhesion molecule-1 Vascular cell adhesion molecule-1 NADPH oxidases 4 Non-obese diabetic mice Urine microalbumin quantitative Periodic acid-Schiff Transmission electron
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