Rotational thromboelastometry results are associated with care level in COVID-19
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Rotational thromboelastometry results are associated with care level in COVID‑19 Lou M. Almskog1,2 · Agneta Wikman3 · Jonas Svensson4 · Michael Wanecek1,5 · Matteo Bottai6 · Jan van der Linden2,7 · Anna Ågren2,8,9 Accepted: 8 October 2020 © The Author(s) 2020
Abstract High prevalence of thrombotic events in severely ill COVID-19 patients have been reported. Pulmonary embolism as well as microembolization of vital organs may in these individuals be direct causes of death. The identification of patients at high risk of developing thrombosis may lead to targeted, more effective prophylactic treatment. The primary aim of this study was to test whether rotational thromboelastometry (ROTEM) at admission indicates hypercoagulopathy and predicts the disease severity, assessed as care level, in COVID-19 patients. The study was designed as a prospective, observational study where COVID-19 patients over 18 years admitted to hospital were eligible for inclusion. Patients were divided into two groups depending on care level: (1) regular wards or (2) wards with specialized ventilation support. Conventional coagulation tests, blood type and ROTEM were taken at admission. 60 patients were included; age 61 (median), 67% men, many with comorbidities (e.g. hypertension, diabetes). The ROTEM variables Maximum Clot Firmness (EXTEM-/ FIBTEM-MCF) were higher in COVID-19 patients compared with in healthy controls (p
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