SCF and APC E3 Ubiquitin Ligases in Tumorigenesis
This SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to b
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Hiroyuki Inuzuka Wenyi Wei
SCF and APC E3 Ubiquitin Ligases in Tumorigenesis
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SpringerBriefs in Cancer Research
For further volumes: http://www.springer.com/series/10786
Hiroyuki Inuzuka • Wenyi Wei
SCF and APC E3 Ubiquitin Ligases in Tumorigenesis
Hiroyuki Inuzuka Department of Pathology Beth Israel Deaconess Medical Center Harvard Medical School Boston, MA, USA
Wenyi Wei Department of Pathology Beth Israel Deaconess Medical Center Harvard Medical School Boston, MA, USA
ISBN 978-3-319-05025-6 ISBN 978-3-319-05026-3 (eBook) DOI 10.1007/978-3-319-05026-3 Springer Cham Heidelberg New York Dordrecht London Library of Congress Control Number: 2014933521 © The Author(s) 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Contents
1
Introduction ............................................................................................... Pengda Liu, Hiroyuki Inuzuka, and Wenyi Wei
2
The Role of FBXW Subfamily of F-box Proteins in Tumorigenesis........................................................................................ Alan W. Lau, Yueyong Liu, Adriana E. Tron, Hiroyuki Inuzuka, and Wenyi Wei
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The Role of FBXL Subfamily of F-box Proteins in Tumorigenesis.........................................................................
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