Scleroderma From Pathogenesis to Comprehensive Management
This essential resource presents the most up-to-date information on scleroderma. A clear and concise synthesis of current concepts in pathogenesis and modern approaches to management, this book is comprised of the authoritative work of international exper
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John Varga
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Christopher P. Denton
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Fredrick M. Wigley
Editors
Scleroderma From Pathogenesis to Comprehensive Management
Editors John Varga, MD John and Nancy Hughes Professor Division of Rheumatology Feinberg School of Medicine Northwestern University Chicago, IL, USA [email protected]
Christopher P. Denton, PhD, FRCP Professor of Experimental Rheumatology Centre for Rheumatology and Connective Tissue Diseases Department of Inflammation Division of Medicine UCL Medical School London, UK [email protected]
Fredrick M. Wigley, MD Professor of Medicine Associate Director Division of Rheumatology Johns Hopkins School of Medicine Baltimore, MD, USA [email protected]
ISBN 978-1-4419-5773-3 e-ISBN 978-1-4419-5774-0 DOI 10.1007/978-1-4419-5774-0 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011942263 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
I gratefully acknowledge Julie, Peter and Andrew Varga for their unfailing support, patience and love; and my patients who each day teach me about scleroderma and honor me with their trust. – John Varga “I am indebted to the ongoing support of my family and the encouragement and guidance from my mentors in rheumatology, especially Dame Carol Black and the late Dr. Barbara Ansell.” – Christopher Denton “I am forever grateful and indebted to Carol, Joy, Julie and family; the entire staff of the Johns Hopkins Scleroderma Center; my colleagues in the Division of Rheumatology and my patients and supporters” – Fred Wigley
Foreword
It was not so long ago that patients with scleroderma had little hope because little was known about the diagnosis, pathogenesis, and treatment of their disease. Although the cause of this disease is still unclear, there have been enormous advances in our understanding of scleroderma during the past decade. Research on the epidemiology, risk fa
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