Post-Traumatic Arthritis Pathogenesis, Diagnosis and Management
Bringing together the most up-to-date research on post-traumatic arthritis (PTA) and its management, this book is a comprehensive presentation of the current thinking on all aspects of the mechanisms of joint injury and subsequent development of PTA. Divi
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Post-Traumatic Arthritis Pathogenesis, Diagnosis and Management
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Post-Traumatic Arthritis
Steven A. Olson • Farshid Guilak Editors
Post-Traumatic Arthritis Pathogenesis, Diagnosis and Management
Editors Steven A. Olson, MD Professor Department of Orthopedic Surgery Duke University Medical Center Durham, NC, USA
Farshid Guilak, PhD Laszlo Ormandy Professor Department of Orthopedic Surgery Duke University Medical Center Durham, NC, USA
ISBN 978-1-4899-7605-5 ISBN 978-1-4899-7606-2 DOI 10.1007/978-1-4899-7606-2
(eBook)
Library of Congress Control Number: 2015939800 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
To Diane and Thomas—Without your love and support, I could not do what I do To Mom and Dad—Thank you for allowing me to pursue my interest in medicine To My Mentors—Bill Allen, Mike Chapman, and Joel Matta—your dedication to excellence inspires me in all I do To Farsh Guilak—Who is a gifted researcher, an unselfish mentor, and a true friend Thank you, Steven A. Olson, MD To Lori, Dina, and Justin, the loves of my life. To my dear parents, Hooshang and Nahid, whose love, support, and inspiration are unparalleled. To the best lab group in the world, who make every day fun, challenging, and exciting. To Steve Olson, an incredible surgeon, scientist, and friend. Thank you, Farshid Guilak, PhD
Foreword
If cancer is the emperor of all maladies, osteoarthritis might be considered to be the peasants and serfs that inhabit the countryside. The American Cancer Society (ACS) estimates that about 15 million people are living today in the USA who have, or have had, some form of cancer. Among this group nearly half are over the age of 70 and the majority were diagnosed over 5 years ago. The ACS also estimates that the total of all healthcare
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