Seasonal Influenza Vaccination and the Heightened Risk of Coronavirus and Other Pandemic Virus Infections: Fact or Ficti
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Above all, a positive frame of mind is of utmost importance to tide over this difficult phase of for us and patients alike. Published online: June 09, 2020; PII: S097475591600189 NITA RADHAKRISHNAN* AND SAVITRI SINGH Department of Pediatric Hematology Oncology, Super Speciality Pediatric Hospital and PG Teaching Institute, Noida, Uttar Pradesh, India *[email protected] REFERENCES
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1. Ministry of health and Family Welfare, Government of India. Enabling Delivery of Essential Health Services during the COVID 19 Outbreak: Guidance note. Available from: https://www.mohfw.gov.in/pdf/ Essential services during COVID19 updated 0411201.pdf. Accessed May 14, 2020. 2. Terenziani M, Massimino M, Biassoni V, Casanova M, Chiaravalli S, Ferrari A, et al. SARS-CoV-2 disease and children under treatment for cancer. Pediatr Blood Cancer. 2020;e28346. 3. Seth R. COVID -19 pandemic: The challenges for pediatric oncology. Indian Pediatr. 2020 May 4 [Early online]. Available from: https://www.indianpediatrics.net/COVID 29.03.2020/CORR-00171.pdf. Accessed June 7, 2020. 4. Ministry of health and Family Welfare, Government of India. Advisory on the use of hydroxyl chloroquine as
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Seasonal Influenza Vaccination and the Heightened Risk of Coronavirus and Other Pandemic Virus Infections: Fact or Fiction?
coronavirus infection appeared both in media and academic circles. The speculation of vaccines paradoxically increasing the risk of infections possibly originated first following 2009 influenza A (H1N1pdm09) pandemic when four Canadian studies suggested that receipt of seasonal influenza vaccine increased the risk of laboratory-confirmed 2009 pandemic influenza A (H1N1pdm09) virus infection [1]. This led to five additional studies, each of which substantiated these initial findings. One proposed mechanism behind this phenomenon is ‘original antigenic sin’ which was first used to describe how first exposure to influenza virus shapes the outcome of subsequent exposures to antigenically related strains. When an individual is
During this ongoing severe acute respiratory illness coronavirus 2 (SARS-CoV-2) pandemic, few speculative reports on significant association of influenza vaccines with an increased risk of
INDIAN PEDIATRICS
prophylaxis for SARS-COV2 Infection. Available from: https://www.mohfw.gov.in/pdf/Advisory on the use of Hydroxychloroquin asprophylaxis for SARS CoV2 infection.pdf. Accessed May 14, 2020. Director General Medical Education, Uttar Pradesh. Quarantine policy document for the health care workers (HCWS) working in COVID hospital/ward. Available from: http://gsvmmedicalcollege.com/wp-content/uploads/2020/ 05/Quarantine-policy-DGME-4.4.2020.pdf. Accessed May 14, 2020. World Health Organization. Health workers exposure risk assessment and management in the context of COVID-19 virus: Interim guidance, 4 March, 2020. Available from: https://apps.who.int/iris/ handle/10665/331340. Accessed May 14, 2020. Ministry of Health and Family Welfare, Government of India. Novel Coronavirus Disease 201
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