Secondary hyperparathyroidism and thoracic vertebral fractures in heart failure middle-aged patients: a 3-year prospecti
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ORIGINAL ARTICLE
Secondary hyperparathyroidism and thoracic vertebral fractures in heart failure middle‑aged patients: a 3‑year prospective study M. Cellini1,6 · S. Piccini1 · G. Ferrante5 · F. Carrone1 · R. Olivetti3 · N. Cicorella4 · M. Aroldi4 · D. Pini5 · M. Centanni6 · A. G. Lania1,2 · G. Mazziotti1,2 Received: 3 January 2020 / Accepted: 23 March 2020 © Italian Society of Endocrinology (SIE) 2020
Abstract Purpose Vertebral fractures (VFs) were described in elderly patients with heart failure (HF) whereas their prevalence and determinants in younger HF patients are still unknown. This study aimed at assessing whether secondary hyperparathyroidism (SHPT) may influence the risk of VFs in middle-aged patients with HF. Methods 84 patients (44 males, median age 48.5 years, range 43–65) with HF were prospectively evaluated at the baseline and after 36-month follow-up for bone mineral density (BMD) and VFs by quantitative morphometry on chest X-rays. Serum PTH, calcium, 25-hydroxyvitamin D and 24-h-urinary calcium were evaluated at the baseline and every 6–12 months during the study period. Results At baseline, SHPT, hypovitaminosis D and VFs were found in 43 patients (51.2%), 73 patients (86.9%) and 29 patients (34.5%), respectively. SHPT was associated with VFs at baseline [inverse probability-weighted (ipw) odds ratio (OR) 12.2, p
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