Secondary pituitary hormonal dysfunction patterns: tumor size and subtype matter
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Secondary pituitary hormonal dysfunction patterns: tumor size and subtype matter Wael M. Almistehi1 · Nadine Vaninetti1 · Syed Mustafa1 · Andrea L. O. Hebb2 · Deborah Zwicker1 · Steve Doucette3 · Saif Alqahtani1 · David B. Clarke1,2 · Syed Ali Imran1
© Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose Patients with sellar masses (SM) frequently have secondary hormonal deficiency (SHD) at initial presentation. While larger SM are more likely to present with SHD, it is unclear whether SHD at presentation is influenced by the type of SM. Methods We conducted a retrospective analysis of patients with SM prospectively enrolled in our comprehensive provincial neuropituitary registry between November 2005 and December 2018. SM were subdivided based on size: 3 cm. Results A total of 914 patients met the inclusion criteria, including: 346 nonfunctioning adenomas (NFA), 261 prolactinomas (PRLoma), 51 growth hormone adenomas, 36 adrenocorticotropic adenomas, 93 Rathke’s cleft cysts, 70 craniopharyngiomas and 57 meningiomas. The overall rate of SHD at presentation was highest in PRLoma (62.8%) and craniopharyngiomas (64.3%) and lowest in meningiomas (14%). While larger SM were significantly more likely to have SHD, the rate of SHD within each group was significantly different despite similar size (p
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