Selective Toxicity The physico-chemical basis of therapy
This book is about selectively toxic agents. That is to say, it is about those substances that affect certain cells without harming others, even when they are close neighbours. Toxicity need not be fatal. It can be made easily reversible, as is the case w
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CHART OF SIZES
Flea 1 mm
Streptococci
- 1(J.ffi-
Molecule (p-aminobenzoic acid) 1nm This chart is to help one remember the relative sizes of Mammals, Insects, Microbes, and Molecules. In each case an example of medium size has been chosen (e.g. Dog and not Whale). Each object is drawn with a magnification 1000 times greater than the object preceding it.
Selective Toxicity The physico-chemical basis of therapy ADRIEN ALBERT D.Sc. (Land.), Ph.D. Medicine (Land.), Fellow of the Australian Academy of Science Professor Emeritus, Department of Chemistry, Australian National University, Canberra; Research Prifessor, Department if Pharmacological Sciences, School ifMedicine, State University ofNew York, Stony Brook.
SEVENTH EDITION
London
New York
Chapman and Hall
First published 1951 Second edition 1960 Third edition 1965 Fourth edition 1968 Reprinted once Fifth edition 1973 Sixth edition 1979 Seventh edition 1985 First paperback edition 1981 Published by Chapman and Hall Ltd 11 New Fetter Lane, London EC4P 4EE Published in the USA by Chapman and Hall 733 Third Avenue, New York NY 10017
©
1985 Adrien Albert
Printed in Great Britain at the University Press, Cambridge ISBN 978-0-412-26020-9 ISBN 978-94-009-4846-4 (eBook) DOI 10.1007/978-94-009-4846-4 This title is available in both hardbound and paperback editions. The paperback edition is sold subject to the condition that it shall not, by way of trade or otherwise, be lent, re-sold, hired out, or otherwise circulated without the publisher's prior consent in any form of binding or cover other than that in which it is published and without a similar condition including this condition being imposed on the subsequent purchaser. All rights reserved. No part of this book may be reprinted, or reproduced or utilized in any form or by any electronic, mechanical or other means, now known or hereafter invented, including photocopying and recording, or in any information storage and retrieval system, without permission in writing from the publisher.
British Library Cataloguing in Publication Data Albert, Adrien Selective toxicity.-!. Chemotherapy 2. Chemistry, Pharmaceutical 3. Drugs--Physiological effect I. Title 615'.7 RM262
Library of Congress Cataloging in Publication Data Albert, Adrien. Selective toxicity. Bibliography: p. Includes indexes. I. Pharmacology. 2. Biological chemistry. 3. Chemotherapy. I. Title. [DNLM: !. Biochemistry. 2. Drug Therapy. 3. Pharmacology. QV 38 A333s] RM301.A361984 615'.7 84-7781
Contents
Preface to Seventh Edition
Xl
PART ONE: TOPICS OF GENERAL INTEREST
1 Selectivity in the service of man 1.0 What is 'Selectivity'? 1.1 Beneficial results from the use of selectivity toxic agents 1.2 The physical basis of selectivity: the three principles
Steps in the correlation of structure with biological action
2.0 The earliest correlations 2.1 The concept of 'receptors'. The receptor as part of an enzyme, permease, or other protein The receptor as part of a nucleic acid The receptor as a coenzyme or other small molecule Reversibility, and
