Sensing the Environment: Regulation of Local and Global Homeostasis by the Skin's Neuroendocrine System

The skin, the body’s largest organ, is strategically located at the interface with the external environment where it detects, integrates and responds to a diverse range of stressors, including solar radiation. It has already been established that the skin

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nuscripts should be addressed to

Co-ordinating Editor Prof. Dr. H.-W. KORF , Zentrum der Morphologie, Universita¨t Frankfurt, Theodor-Stern Kai 7, 60595 Frankfurt/Main, Germany e-mail: [email protected]

Editors Prof. Dr. F. BECK, Howard Florey Institute, University of Melbourne, Parkville, 3000 Melbourne, Victoria, Australia e-mail: [email protected] ´ , Department of Anatomy, Histology and Neurobiology Prof. Dr. F. CLASCA Universidad Auto´noma de Madrid, Ave. Arzobispo Morcillo s/n, 28029 Madrid, Spain e-mail: [email protected] Prof. Dr. D.E. HAINES, Ph.D., Department of Anatomy, The University of Mississippi Med. Ctr., 2500 North State Street, Jackson, MS 39216–4505, USA e-mail: [email protected] Prof. Dr. N. HIROKAWA, Department of Cell Biology and Anatomy, University of Tokyo, Hongo 7–3–1, 113-0033 Tokyo, Japan e-mail: [email protected] Dr. Z. KMIEC, Department of Histology and Immunology, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland e-mail: [email protected] Prof. Dr. R. PUTZ, Anatomische Anstalt der Universita¨t Mu¨nchen, Lehrstuhl Anatomie I, Pettenkoferstr. 11, 80336 Mu¨nchen, Germany e-mail: [email protected] Prof. Dr. J.-P. TIMMERMANS, Department of Veterinary Sciences, University of Antwerpen, Groenenborgerlaan 171, 2020 Antwerpen, Belgium e-mail: [email protected]

212 Advances in Anatomy, Embryology and Cell Biology

Co-ordinating Editor H.-W. Korf, Frankfurt

Editors F.F. Beck • F. Clasca´ • D.E. Haines • N. Hirokawa Z. Kmiec • R. Putz • J.-P. Timmermans For further volumes: http://www.Springer.com/series/102

Andrzej T. Slominski, Michal A. Zmijewski, Cezary Skobowiat, Blazej Zbytek, Radomir M. Slominski, Jeffery D. Steketee

Sensing the Environment: Regulation of Local and Global Homeostasis by the Skin’s Neuroendocrine System With 23 figures

Andrzej T. Slominski University of Tennessee Health Science Center Department of Pathology and Laboratory Medicine, and Department of Medicine Memphis, TN, USA [email protected] Michal A. Zmijewski Medical University of Gdansk Department of Histology Gdansk, Poland Cezary Skobowiat University of Tennessee Health Sciences Center Department of Pathology and Laboratory Medicine Memphis, TN, USA

Blazej Zbytek University of Tennessee Health Science Center Department of Pathology and Laboratory Medicine Memphis, TN, USA Radomir M. Slominski University of Tennessee Health Science Center Memphis, TN, USA and Jagiellonian University Medical College Krakow, Poland Jeffery D. Steketee University of Tennessee Health Science Center Department of Pharmacology Memphis, TN, USA

ISSN 0301-5556 ISBN: 978-3-642-19682-9 ISBN: 978-3-642-19683-6 (eBook) DOI: 10.1007/978-3-642-19683-6 Springer Heidelberg New York Dordrecht London Library of Congress Control Number: 2012939853 # Springer-Verlag Berlin Heidelberg 2012 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse o