Serum Growth Arrest-Specific Protein 6 Levels are a Reliable Biomarker of Disease Activity in Systemic Lupus Erythematos
- PDF / 224,717 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 84 Downloads / 165 Views
ORIGINAL RESEARCH
Serum Growth Arrest-Specific Protein 6 Levels are a Reliable Biomarker of Disease Activity in Systemic Lupus Erythematosus Hyoun-Ah Kim & Jin-Young Nam & Ja-Young Jeon & Jeong-Mi An & Ju-Yang Jung & Chang-Bum Bae & Chang-Hee Suh
Received: 20 June 2012 / Accepted: 9 August 2012 / Published online: 23 August 2012 # Springer Science+Business Media, LLC 2012
Abstract Purpose Growth arrest-specific protein 6 (Gas6) has been suggested to be a biomarker of disease activity in patients with systemic lupus erthematosus (SLE). We investigated the clinical significance of this protein in Korean SLE. Methods Blood samples were collected from 150 SLE patients and 50 normal controls (NC). In addition, followup samples were collected from 50 SLE patients. Results Serum Gas6 levels of SLE patients (43.01 ± 28.02 ng/mL) were higher than those of NC (20.15 ± 9.23 ng/mL, p< 0.001). When evaluated sensitivity and specificity of the Gas6 for diagnosing SLE using ROC curves, the sensitivity and specificity were 72.7 % and 84 % with a cut-off value of 25.3 ng/mL. In the ROC analysis of Gas6, anti-dsDNA antibody, ESR, complement 3 and complement 4 to identify patients with active lupus, area under the curve (AUC) of Gas6 was highest with 0.763. Serum Gas6 levels were significantly higher in the patients with serositis (70.04 ± 30.85 ng/mL) and renal disorder (65.66 ±32.28 ng/mL) compared to those without (41.88± 27.44 ng/mL, p00.033, 40.3±26.33 ng/mL, p00.001, respectively). Gas6 levels were correlated positively with antidsDNA antibody (r00.199, p00.015), ESR (r00.204, p0 0.013) and SLEDAI (r00.512, p
Data Loading...
