Serum hydroxybutyrate dehydrogenase as an early predictive marker of the severity of acute pancreatitis: a retrospective
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RESEARCH ARTICLE
Open Access
Serum hydroxybutyrate dehydrogenase as an early predictive marker of the severity of acute pancreatitis: a retrospective study Weiming Xiao1,2*†, Weili Liu3†, Ling Yin3†, Yong Li3, Guotao Lu1,2, Xinnong Liu2,4, Weijuan Gong1,2, Yanbing Ding1,2, Mei Wang1,2 and Zhigang Yan1,2*
Abstract Background: To investigate the value of serum hydroxybutyrate dehydrogenase (HBDH) level, an isozyme of lactate dehydrogenase, in evaluating the severity of acute pancreatitis (AP). Methods: Patients diagnosed with AP from January 2013 to December 2018 were included in this retrospective study. Patients were divided into the normal serum HBDH levels group (n-HBDH group) and the high serum HBDH levels group (h-HBDH group) according to the criteria HBDH ≥ 182 U/L after admission. The demographic parameters, laboratory data and the severity of AP in the two groups were compared. The receiver operating curve (ROC) was used to evaluate the efficacy of serum HBDH in predicting persistent organ failure and systemic inflammatory response syndrome (SIRS). Results: A total of 260 AP patients were enrolled, including 176 cases in the n-HBDH group and 84 cases in the h-HBDH group. The incidence of SIRS and organ failure in the h-HBDH group were significantly higher than those in n-HBDH group (both P 10%. In addition, other conditions that may
Xiao et al. BMC Gastroenterol
(2020) 20:393
cause the above acute abnormal changes should be excluded [17]. Statistical analysis
All continuous variables were represented as the mean ± standard deviation (SD). Data were analysed with SPSS 16.0 (SPSS Inc., Chicago, USA). Independent sample t test and chi-square test were used to compare continuous variables and categorical variables, respectively. Pearson correlation analysis was used to examine the correlation between serum HBDH levels and other laboratory indicators. Receiver operating characteristic (ROCs) curves were applied to assess the sensitivity and specificity of the indicators by GraphPad Prism 5.0 software. A bilateral P
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