Serum levels of galactose-deficient IgA1 in Chinese children with IgA nephropathy, IgA vasculitis with nephritis, and Ig
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ORIGINAL ARTICLE
Serum levels of galactose‑deficient IgA1 in Chinese children with IgA nephropathy, IgA vasculitis with nephritis, and IgA vasculitis Mengmeng Tang1 · Xue Zhang2,3,4,5 · Xueqian Li1 · Lei Lei1 · Hejia Zhang1 · Chen Ling1 · Jie Ni1 · Jicheng Lv2,3,4,5 · Xiaorong Liu1 · Xiangmei Chen6 Received: 6 May 2020 / Accepted: 26 August 2020 © Japanese Society of Nephrology 2020
Abstract Objective IgA nephropathy (IgAN) and IgA vasculitis with nephritis (IgAV-N) are related diseases. Galactose-deficient IgA1 (Gd-IgA1) plays an important role in the pathology of IgAV-N and IgAN, so we aim to compare the serum levels of Gd-IgA1 in Chinese pediatric patients with IgAN, IgAV-N, and IgAV. Methods We retrospectively enrolled 52 patients with IgAN, 57 patients with IgAV-N, 26 patients with IgAV, and 40 healthy children. The serum levels of Gd-IgA1 were measured at the time of biopsy using a lectin-based ELISA method. Results Gd-IgA1 levels in IgAV-N patients and IgAN patients were higher than in healthy controls (303.94 ± 39.37 U/ml, 314.91 ± 47.79 U/ml vs. 273.57 ± 48.29 U/ml, P
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